中文摘要：脱氧雪腐镰刀菌烯醇(DON)是一种最普遍的单端孢霉烯毒素，主要由禾谷镰刀菌产生。人们对孕期DON暴露或DON暴露水平的影响知之甚少。本研究旨在通过液相色谱-质谱法(LC-MS)分析，提供有关孕妇尿样中总DON和脱环氧脱氧雪腐镰刀菌烯醇(DOM-1)含量的数据。本研究提供了郊区孕妇DON含量的相关数据并保证这些含量在可接受范围内。
外文摘要：Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provide data on levels of total DON and de-epoxi Deoxynivalenol (DOM-1) in pregnant human urine samples analysed by liquid chromatography-mass spectrometry (LC-MS). Morning urine samples were collected over two consecutive days from 42 volunteers and associated food consumption was recorded for the 24 h prior to the sample. Spearman's rho non-parametric test for correlation was used to assess the data. Levels of DON did not differ significantly between day 1 (mean 29.7 ng/mL urine or 40.1 ng DON/mg creatinine) and day 2 (mean 28.7 ng/mL urine or 38.8 ng DON/mg creatinine ng/mL/day) urine samples. The only significant positive correlation was found between total ng DON/mg creatinine and parity (rho = 0.307, n = 42, p < 0.005 two-tailed) and total ng DON/mg creatinine with baked goods on day 1 (rho = 0.532, n = 42, p < 0.0005 two-tailed). This study provides data on the DON levels in pregnancy in this suburban population and reassurance that those levels are within acceptable limits.
外文关键词：mycotoxins；Deoxynivalenol；pregnancy；vomitoxin
作者：Wells, L；Hardie, L；Williams, C；White, K；Liu, Y；De Santis, B；Debegnach, F；Moretti, G；Greetham, S；Brera, C；Rigby, A; Atkin, S；Sathyapalan, T
作者单位：Hull Royal Infirm
期刊名称：TOXINS
期刊影响因子：3.571
出版年份：2016
出版刊次：11
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