中文摘要：本研究在遵循各自饮食习惯的前提下，评估了乳糜泻患者人群(n = 55)和对照健康人群（n=50）霉菌毒素暴露的尿生物标志物。研究结果表明尽管腹腔疾病和健康人群自由生活普遍存在的饮食暴露强调有必要持续监测霉菌毒素，但对无麸质产品具体监管的紧迫性很小。
外文摘要：Urinary biomarkers of mycotoxin exposure were evaluated in a group of celiac patients (n = 55) and in a control group of healthy subjects (n = 50) following their habitual diet. Deoxynivalenol (DON), zearalenone (ZEN), and fumonisin B1 (FB1) were monitored in 105 urinary samples collected from the two groups. Dietary habits were also recorded through compilation of a seven-day weighed dietary diary. Biomarkers of mycotoxin exposure were detected in 21 celiac patients and in 15 control subjects, corresponding to about 34% of total participants. In particular, ZEN was the most detected mycotoxin among all the studied subjects with a total of 19 positive cases. Results did not show a statistically significant difference in mycotoxin exposure between the two groups, and the presence of specific mycotoxins was not related to the intake of any particular food category. Our findings suggest little urgency of specific regulation for gluten free products, although the prevalence of exposure observed in free-living diets of both celiac and healthy subjects underlines the need of a constant surveillance on mycotoxins occurrence at large.
外文关键词：deoxynivalenol (DON)；zearalenone (ZEN)；fumonisin B1 (FB1)；human urine；celiac patients
作者：Cirlini, M；Mazzeo, T；Roncoroni, L；Lombardo, V；Elli, L；Bardella, MT；Agostoni, C；Doneda, L；Brighenti, F；Dall'Asta, C；Pellegrini, N
作者单位：Univ Parma
期刊名称：TOXINS
期刊影响因子：3.571
出版年份：2017
出版刊次：1
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