中文摘要：隐蔽型霉菌毒素是霉菌毒素的植物代谢物，污染食品及饲料。全球因缺乏毒理学资料而监管不力，引起健康问题。本文研究掩蔽型霉菌毒素14-葡萄糖苷玉米赤霉烯酮的毒理学相关性。研究认为除评估隐蔽型霉菌毒素的吸收、生物利用度及生物有效性外，还应评估其系统水解，以便深入了解其毒性。
外文摘要：Masked mycotoxins are plant metabolites of mycotoxins that contaminate food and feed. They pose health concern as the shortage of toxicological data forces the lack of regulation worldwide. The present work investigated the toxicological relevance of the masked mycotoxin zearalenone-14-glucoside. In vitro, it shows a lower toxicity in respect to the parent compound. However, the major risks related to the consumption of masked mycotoxins depend on the possibility to undergo hydrolysis. Therefore, the hydrolysis and further transformation of zearalenone-14-glucoside in bovine blood and blood components (i.e. plasma, serum and serum albumin) were monitored using LC/MS-MS analysis to gain insights on the possible systemic fate. Hydrolysis was observed in all matrices, and both cell-dependent and –independent contributions were pointed out. Moreover, further metabolism was observed in the whole blood as zearalenol isomers were found. Serum albumin was identified among the active components, and the protein-ligand interaction was investigated via computational analysis. The blood has been pointed out as possible district of reversion and further activation of zearalenone-14-glucoside, and a similar fate cannot be excluded for other masked mycotoxins. Therefore, the systemic hydrolysis should be evaluated beside the absorption, bioavailability and bioaccessibility to deeply understand the toxicity of masked mycotoxins.
外文关键词：Biotransformation；In silico/in vitro approach；Masked mycotoxins；Serum albumin；Zearalenone；Zearalenone-14-glucoside
作者：Dellafiora, L；Galaverna, G；Righi, F；Cozzini, P；Dall'Asta, C
作者单位：Univ Parma
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.584
出版年份：2017
出版刊次：1
点击下载：隐蔽型霉菌毒素14-葡萄糖苷玉米赤霉烯酮的水解命运评估：一个需要注意隐蔽型霉菌毒素的警示