中文摘要：根据欧盟规定，转基因植物有过敏性，因而在投入欧盟市场前必须评估其内源性过敏原，这与食品法典委员会所描述的国际准则一致。在这种前提下，与常规作物相比，转基因植物相关过敏原的定量增加可能会产生非预期的效应，这种非预期的效应可能给消费者带来风险。由于没有充分理解过敏的病理生理机制，因而揭示剂量和过敏间联系的数据很少。大豆是目前唯一被法律认可的过敏性转基因食品，本文以转进因大豆为来实施一个评估策略。本文对潜在过敏原的鉴定、定量方法、及风险评估的注意事项进行了讨论。作者提出了一种识别、评估和评价转基因作物的内源性致敏性潜在危害/风险的策略。这种方法可在未来需要时扩展到其他过敏性食品。
外文摘要：According to EU regulation, genetically modified (GM) plants considered to be allergenic have to be assessed concerning their endogenous allergens before placement on the EU market, in line with the international standards described in Codex Alimentarius. Under such premises, a quantitative relevant increase in allergens might occur in GM plants as an unintended effect compared with cdnventionally produced crops, which could pose a risk to consumers. Currently, data showing a connection between dose and allergic sensitisation are scarce since the pathophysiological mechanisms of sensitisation are insufficiently understood. In contrast, data on population dose-distribution relationships acquired by oral food challenge are available showing a connection between quantity of allergenic protein consumed and the population of allergic individuals experiencing reactions. Soybean is currently the only recognised allergenic GM food by law for which EFSA has received applications and was therefore taken as an example for defining an assessment strategy. Identification of potential allergens, methodology for quantification as well as risk assessment considerations, are discussed. A strategy is proposed for the identification, assessment and evaluation of potential hazards/risks concerning endogenous allergenicity in food derived from plants developed by biotechnology. This approach could be expanded to other allergenic foods in the future, whenever required.
外文关键词：Endogenous allergenicity; Genetically modified plants; GMO; Soybean; Food allergy
作者：Selb, R.; Wal, J. M.; Moreno, F. J.; 等
作者单位：European Food Safety Author
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.584
出版年份：2017
出版刊次：3
点击下载：我们对转基因作物如转基因大豆的内源过敏性评价应站在什么位置？