中文摘要：黄曲霉毒素、伏马菌素及赭曲霉毒素A污染多种农产品，具有显著毒性及人类致癌性。本研究采用总膳食研究法评估越南老街省成人上述毒素的膳食暴露情况。研究发现还需进一步研究评估减少霉菌毒素污染的技术解决方案的效率以及确定不同类型霉菌毒素的共同暴露对健康的影响。
外文摘要：Aflatoxins, fumonisins and ochratoxin A that contaminate various agricultural commodities are considered of significant toxicity and potent human carcinogens. This study took a total dietary study approach and estimated the dietary exposure of these mycotoxins for adults living in Lao Cai province, Vietnam. A total of 42 composite food samples representing 1134 individual food samples were prepared according to normal household practices and analysed for the three mycotoxins. Results showed that the dietary exposure to aflatoxin B1 (39.4 ng/kg bw/day) and ochratoxin A (18.7 ng/kg bw/day) were much higher than recommended provisional tolerable daily intake (PTDI) values mainly due to contaminated cereals and meat. The exposure to total fumonisins (1400 ng/kg bw/day) was typically lower than the PTDI value (2000 ng/kg bw/day). The estimated risk of liver cancer associated with exposure to aflatoxin B1 was 2.7 cases/100,000 person/year. Margin of exposure (MOE) of renal cancer linked to ochratoxin A and liver cancer associated with fumonisins were 1124 and 1954, respectively indicating risk levels of public health concern. Further studies are needed to evaluate the efficiency of technical solutions which could reduce mycotoxin contamination as well as to determine the health effects of the co-exposure to different types of mycotoxins.
外文关键词：Risk assessment；Total diet study；Aflatoxin B1；Ochratoxin A；Fumonisins；Viet Nam
作者：Huong, BTM；Tuyen, LD；Tuan, DH；Brimer, L；Dalsgaard, A
作者单位：Univ Copenhagen
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.584
出版年份：2016
出版刊次：12
点击下载：越南老街省成人黄曲霉毒素B1、赭曲霉毒素A及伏马菌素膳食暴露：总膳食研究法