中文摘要：基于植物种子的鸽粮可能会使鸽子暴露于霉菌毒素如脱氧雪腐镰刀菌烯醇（DON）。摄入低至中度污染水平的DON可能损害肠道健康、免疫功能和/或病原体适合度，改变宿主-病原体的相互作用，从而导致不同的感染结果。本风险评估结果表明鸽子经常受到霉菌毒素如DON的暴露，对沙门氏菌感染的结果有影响。越来越多的鸽子脱落沙门氏菌表明DON能促进细菌在鸽群中的传播。
外文摘要：Seed-based pigeon diets could be expected to result in exposure of pigeons to mycotoxins such as deoxynivalenol (DON). Ingestion of low to moderate contamination levels of DON may impair intestinal health, immune function and/or pathogen fitness, resulting in altered host-pathogen interactions and thus different outcome of infections. Here we demonstrate that DON was one of the most frequently detected mycotoxins in seed-based racing pigeons feed, contaminating 5 out of 10 samples (range 177-1,466 μg/kg). Subsequently, a toxicokinetic analysis revealed a low absolute oral bioavailability (F) of DON in pigeons (30.4%), which is comparable to other avian species. Furthermore, semi-quantitative analysis using high-resolution mass spectrometry revealed that DON-3α-sulphate is the major metabolite of DON in pigeons after intravenous as well as oral administration. Following ingestion of DON contaminated feed, the intestinal epithelial cells are exposed to significant DON concentrations which eventually may affect intestinal translocation and colonization of bacteria. Feeding pigeons a DON contaminated diet resulted in an increased percentage of pigeons shedding Salmonella compared to birds fed control diet, 87 ± 17% versus 74 ± 13%, respectively. However, no impact of DON was observed on the Salmonella induced disease signs, organ lesions, faecal and organ Salmonella counts. The presented risk assessment indicates that pigeons are frequently exposed to mycotoxins such as DON, which can affect the outcome of a Salmonella infection. The increasing number of pigeons shedding Salmonella suggests that DON can promote the spread of the bacterium within pigeon populations.
作者：Antonissen, G；Haesendonck, R；Devreese, M；Broekaert, N；Verbrugghe, E；De Saeger, S；Audenaert, K；Haesebrouck, F；Pasmans, F；Ducatelle, R；Croubels, S；Martel, A
作者单位：Univ Ghent
期刊名称：PLOS ONE
期刊影响因子：3.057
出版年份：2016
出版刊次：12
点击下载：脱氧雪腐镰刀菌烯醇对鸽子健康的影响：污染鸽粮、毒代动力学及与沙门氏菌相互作用