中文摘要：肝细胞癌(HCC)是最常见的肝恶性肿瘤。作为致癌物，黄曲霉毒素B１（AFB１）通过诱导脱氧核糖核酸加合物引起肝细胞基因变化引发HCC并可能是HCC发生率高达30%的原因。HCC的发病率持续上升并成为了巴尔干西部国家的一大问题。本文介绍了一名37岁的女性，她被诊断患上了HCC，而无B型和C型肝炎或肝硬化病史。过去20年中，该患者每天消费超过2升的大量牛奶和乳制品，表明牛奶中的黄曲霉毒素对HCC有影响。内部用免疫过氧化物酶筛选试验通过ELISA（酶联免疫吸附试验）检测到了黄曲霉毒素B1的存在。由此得出如下结论：作为致癌的呋喃香豆素衍生物，黄曲霉毒素B1是肝细胞恶性转化最可能的原因，其导致了该女性患上肝细胞癌。
外文摘要：Introduction. Hepatocellular carcinoma (HCC) is the most frequent type of liver malignancy. As a carcinogen, aflatoxin B1 (AFB1) causes HCC by inducing deoxyribonucleic acid adducts that lead to genetic changes in liver cells and may be the cause of HCC in up to 30% of cases. The incidence of HCC has been on the rise and is an issue in the countries of the Western Balkans. Case Outline. This paper presents a case of a 37-year-old woman who was diagnosed with HCC, without hepatitis B, hepatitis C, or liver cirrhosis. The patient consumed milk and dairy products in quantities of over two liters per day over the course of 20 years, which indicates the impact of aflatoxin in milk on HCC. A positive signal for the presence of AFB1 was detected by ELISA (enzyme-linked immunosorbent assay) in-house using immunoperoxidase screening test. Conclusion. As carcinogenic difuranocoumarin derivative, aflatoxin B1 is the most likely cause of malignant transformation of hepatocytes, which resulted in hepatocellular carcinoma in this patient.
外文关键词：aflatoxin molecule；hepatocarcinogenic；hepatocellular carcinoma；Vojvodina
作者：Ilic, M；Putnik, SS；Prvulovic-Bunovic, N；Vojinovic-Miloradov, M；Mihajlovic, I；Turk-Sekulic, M；Radonic, J
作者单位：Inst Pulm Dis Vojvodina
期刊名称：SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
期刊影响因子：0.277
出版年份：2016
出版刊次：11-12
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