中文摘要：通过添加碱性水解步骤进QuEChERS方法实现对酸性农药及其酯类的同时检测，已经获得认可，但是该过程导致了大多数苯氧酸酯类化合物的水解。本文在代谢研究资料、现场实验监督水解条件以及温度、时间、溶剂类型、基质类型等物理化学参数对结果的影响研究的基础上，发现30分钟40摄氏度下的碱性水解对2,4-滴丙酸、吡氟禾草灵、盖草能、2-甲-4-氯苯氧基乙酸、2甲4氯丁酸农药残留同时检测效果较好。通过对不涉及方法开发的六个德国实验室残留物的分析证实了该方法的实用性，采用带有碱性水解步骤的QuEChERS萃取方法可检测出高出六倍的残留物。
外文摘要：An analytical procedure was developed allowing the simultaneous determination of acidic pesticides and their conjugates by addition of an alkaline hydrolysis step into the European Union (EU) version of the QuEChERS method. The procedure resulted additionally in hydrolysis of most esters of phenoxy acids. On the basis of information from metabolism studies and the hydrolytic conditions employed in supervised field trials as well as results on the influence of physical and chemical parameters (temperature, time, type of solvent, type of matrix), alkaline hydrolysis for 30 min at 40 degrees C was deemed a good compromise for the determination of residues of 2,4-D, dichlorprop, fluazifop, haloxyfop, MCPA, and MCPB. The applicability of the proposed method was tested by analyzing food samples with incurred residues in six German laboratories not involved in method development. Up to 6 times higher residues are measured by using the QuEChERS extraction procedure with the newly developed alkaline hydrolysis step.
 
外文关键词：acidic pesticides, QuEChERS method, alkaline hydrolysis, LC-MS/MS, EU reference method
作者：Steinborn, Angelika; Alder, Lutz; Spitzke, Madeleine; Doerk, Daniela; Anastassiades, Michelangelo
作者单位：Fed Inst Risk Assessment, Dept Pesticides Safety, Max Dohrn Str 8-10, D-10589 Berlin, Germany.
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
期刊影响因子：2.857
出版年份：2017
出版刊次：2
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