中文摘要：普遍存在于多种食品中的黄曲霉毒素暴露与撒哈拉以南非洲儿童生长障碍有关。为了提高人们对黄曲霉毒素及其他危险因素的生长损伤的认识，本研究评估了从尼泊尔采集的15、24、36月儿童的生物检材的黄曲霉毒素暴露情况。研究发现受访孩童低水平的黄曲霉毒素暴露及罕见的发育迟缓、消瘦，或体重过轻的Z值可能是导致协会缺乏证据的原因。还需进一步研究是否存在诱发儿童生长障碍的黄曲霉毒素的临界剂量。
外文摘要：Exposure to aflatoxin, a mycotoxin common in many foods, has been associated with child growth impairment in sub-Saharan Africa. To improve our understanding of growth impairment in relation to aflatoxin and other risk factors, we assessed biospecimens collected in Nepalese children at 15, 24, and 36 months of age for aflatoxin exposure. Children (N = 85) enrolled in the Bhaktapur, Nepal MAL-ED study encompassed the cohort analysed in this study. Exposure was assessed through a plasma biomarker of aflatoxin exposure: the AFB1-lysine adduct. The aflatoxin exposures in the study participants were compared to anthropometrics at each time period (length-for-age [LAZ], weight-for-age [WAZ], and weight-for-length [WLZ] z-scores), growth trajectories over time, age, and breastfeeding status. Results demonstrated chronic aflatoxin exposure in this cohort of children, with a geometric mean of 3.62 pg AFB1-lysine/mg albumin. However, the chronic aflatoxin exposure in this cohort was not significantly associated with anthropometric z-scores, growth trajectories, age, or feeding status, based on the available time points to assess aflatoxin exposure. Low mean levels of aflatoxin exposure and infrequent occurrence of stunting, wasting, or underweight z-score values in this cohort are possible contributing factors to a lack of evidence for an association. Further research is needed to examine whether a threshold dose of aflatoxin exists that could induce child growth impairment.
作者：Mitchell, NJ；Hsu, HH；Chandyo, RK；Shrestha, B；Bodhidatta, L；Tu, YK；Gong, YY；Egner, PA；Ulak, M；Groopman, JD；Wu, F
作者单位：Michigan State Univ
期刊名称：PLOS ONE
期刊影响因子：3.057
出版年份：2017
出版刊次：2
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