中文摘要：本文开发并验证了一种用于同时检测高含水量植物（生菜、白菜、番茄）组织中28种污水污染物及其代谢物（比如，卡马西平、卡马西平10,11-环氧化物、苯并三氮唑、拉莫三嗪以及双氯芬酸）的分析方法。该方法具有固-液萃取、不需要清洗步骤、带有正负模式电喷雾的液相色谱-串联质谱检测等功能，且与QuEChERS方法相比，该方法具有更好的分析性能。采用该方法对四种不同基质（卷心菜、生菜、番茄叶和番茄）进行检测，检测限干重小于等于2.0 ng/g，绝对回收率大于>60%，日内和日间精度较高，相对标准差小于10%，可实现71%的目标分析物检测。与QuEChERS方法相比，该方法可检测不同理化性质（中性、酸性和碱性）的化合物并考虑到了其代谢物。该方法成功地应用于测定城市污水灌溉的温室和田间植物污染物残留。因此，该方法适用于对处理后污水灌溉的植物及其可食用部分的化合物及其代谢物的检测，鉴于其广泛的提取方法，该方法还适用于与高分辨率质朴法联用筛选未知污染物及其代谢物。
外文摘要：An analytical method for the simultaneous determination of 28 wastewater-derived contaminants and possible metabolites (e.g. carbamazepine, 10,11-epoxy-carbamazepine, benzotriazole, lamotrigine, and diclofenac) in common plant tissues with high water content (lettuce, cabbage, and tomato) was developed and validated. The developed method combines solid-liquid extraction, without the need for a clean-up step, and liquid chromatography-tandem mass spectrometry (LC-MS/MS) with electrospray ionization in positive and negative modes.This method was compared with the known QuEChERS method and exhibited better analytical performance. Method detection limits of <= 2.0 ng g(-1) dry weight and absolute recoveries of >60% with high intra- and inter-day precision (RSD < 10%) could be achieved for 71% of the target analytes in four different matrices (cabbage, lettuce and tomato leaves, and tomato fruits). Compared to the QuEChERS method, the developed method allows the determination of a wide range of compounds with different physical-chemical properties (neutral, acidic, and basic) and considers even possible metabolites of pharmaceuticals in plant materials. The developed method was successfully applied to analyse wastewater-derived contaminants and their metabolites in plants which were grown under greenhouse and real field conditions. It could be shown that this method is suitable for the sensitive determination of environmental contaminants originating from treated wastewater and a range of their metabolites in irrigated plants and their edible parts. Due to its broadness the extraction method should also be suitable for screening of unknown contaminants and metabolites by LC high-resolution mass spectrometry.
 
外文关键词：PERSONAL CARE PRODUCTS; TANDEM MASS-SPECTROMETRY; SOLID-PHASE EXTRACTION; LIQUID-CHROMATOGRAPHY; PESTICIDE-RESIDUES; MULTIRESIDUE METHOD; SOLVENT-EXTRACTION; PLANT UPTAKE; PHARMACEUTICALS; CARBAMAZEPINE
作者：Riemenschneider, Christina; Seiwert, Bettina; Goldstein, Myah;Al-Raggad, Marwan; Salameh, Elias; Chefetz, Benny; Reemtsma, Thorsten
作者单位：UFZ Helmholtz Ctr Environm Res, Dept Analyt Chem, Permoserstr 15, D-04318 Leipzig, Germany
期刊名称：ANALYTICAL METHODS
期刊影响因子：1.9
出版年份：2017
出版刊次：6
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