中文摘要：串珠镰刀菌（有性型，串珠状赤霉菌）是重要的植物病源菌，引起玉米(Zea mays)苗期枯萎病、茎腐病和穗腐病。感染后，串珠镰刀菌产生伏马菌素B1（FB1），对人畜健康造成严重的威胁。最近的研究表明Set1，一种H3K4甲基转移酶，负责丝状真菌毒素的生物合成。然而，FvSet1对FB1生物合成的调节至今不明。本研究仅鉴定了一个串珠镰刀菌的Set1同源物(FvSet1)，并发现FvSet1的缺失导致了真菌各种生长及致病性缺陷。表明在串珠镰刀菌中，FvSet1对调节FB1的生物合成、真菌生长及毒性，以及胁迫响应起着至关重要的作用。
外文摘要：Fusarium verticillioides (teleomorph, Gibberella moniliformis) is an important plant pathogen that causes seedling blight, stalk rot, and ear rot in maize (Zea mays). During infection, F. verticillioides produce fumonsins B1 (FB1) that pose a serious threat to human and animal health. Recent studies showed that Set1, a methyltransferase of H3K4, was responsible for toxin biosynthesis in filamentous fungi. However, to date, the regulation of FvSet1 on FB1 biosynthesis remains unclear. In the current study, we identified only one Set1 ortholog in F. verticillioides (FvSet1) and found that the deletion of FvSET1 led to various defects in fungal growth and pathogenicity. More interestingly, the FvSET1 deletion mutant (ΔFvSet1) showed a significant defect in FB1 biosynthesis and lower expression levels of FUM genes. FvSet1 was also found to play an important role in the responses of F. verticillioides to multiple environmental stresses via regulating the phosphorylation of FvMgv1 and FvHog1. Taken together, these results indicate that FvSet1 plays essential roles in the regulation of FB1 biosynthesis, fungal growth and virulence, as well as various stress responses in F. verticillioides.
外文关键词：Fusarium verticillioides；FvSet1；fumonisin B1；fungal growth and virulence；stress responses
作者：Gu, Q；Tahir, HAS；Zhang, H；Huang, H；Ji, TT；Sun, X；Wu, LM；Wu, HJ；Gao, XW
作者单位：Nanjing Agr Univ
期刊名称：TOXINS
期刊影响因子：3.571
出版年份：2017
出版刊次：2
点击下载：FvSet1参与串珠镰刀菌伏马菌素B1的生物合成、营养生长、真菌毒力及环境胁迫的响应