中文摘要：鲁米诺与Ru(bpy)32+分子间电化学发光共振能量转移(ECL-RET) 已有了广泛的研究，由于供体和受体间完美的光谱重叠，能实现灵敏地生物分析，但它仍然面临着能量转移效率低的挑战性问题。本文设计并研究了分子内ECL-RET转移到新型ECL化合物，包含鲁米诺供体及Ru(bpy)2(mcpbpy)2+受体(Lum-Ru)。该传感平台也为临床中分析其他生物分子的痕量检测提供了有力的推动。
 
外文摘要：The intermolecular electrochemiluminescence resonance energy transfer (ECL-RET) between luminol and Ru(bpy)32+ was studied extensively to achieve the sensitive bioanalysis owing to the perfect spectral overlap of the donor and acceptor, but it still suffers from the challenging issue of low energy-transfer efficiency. The intramolecular ECL-RET towards the novel ECL compound containing the donor of luminol and the acceptor of Ru(bpy)2(mcpbpy)2+ (Lum-Ru) was designed and investigated. With the high-efficient ECL-RET in one molecule, the highly intense ECL signal of Lum-Ru was obtained owing to the short path of energy transmission and less energy loss between luminol and Ru(bpy)2(mcpbpy)2+. Lum-Ru was further applied to construct a signal-off electrochemiluminescence (ECL) aptasensor for ultrasensitive detection of a harsh carcinogen of Aflatoxin M1 (AFM1). This sensing platform also provides a significant boost for the trace detection of other biomolecules in clinical analysis.
外文关键词：Aflatoxin M1；electrochemiluminescence；resonance energy transfer；ruthenium；target-induced circular exponential amplification
作者：Liu, JL；Zhao, M；Zhuo, Y；Chai, YQ；Yuan, R
作者单位：Southwest Univ
期刊名称：CHEMISTRY-A EUROPEAN JOURNAL
期刊影响因子：5.771
出版年份：2017
出版刊次：8
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