中文摘要：银纳米粒子（AgNPs）作为抗菌材料已被广泛研究，但尚未研究它们抑制黄曲霉毒素产生的能力。本研究合成了平均大小为4.5nm的AgNPs，用于抑制黄曲霉(A. flavus)的生长。本文尝试研究AgNP诱导的产黄曲霉毒素的抑制作用及其可能的机理尚属首次。
外文摘要：Silver nanoparticles (AgNPs) have been extensively studied as antimicrobial materials, but their capability of suppressing aflatoxin production has not been investigated. In this work, AgNPs with an average size of 4.5 nm were synthesized to inhibit the growth of Aspergillus flavus (A. flavus). Based on the anti-fungal assay, the concentration of 5 μg mL−1 was chosen to study the direct inhibiting effects of AgNPs on aflatoxin production. Results show that AgNP treatment could significantly decrease secretion of aflatoxin B1 from A. flavus. Real-time measurements of O2− with an electrochemical sensor reveal that the AgNPs could trigger the release of O2− from fungal mycelia. A mechanism involving O2− release is proposed to explain AgNP-caused depression of aflatoxin production from A. flavus. This is the first attempt to study AgNP-induced inhibition on aflatoxin generation and its possible mechanisms.
作者：Zhao, J；Wang, L；Xu, D；Lu, ZS
作者单位：Southwest Univ
期刊名称：RSC ADVANCES
期刊影响因子：3.289
出版年份：2017
出版刊次：37
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