中文摘要：脱氧雪腐镰刀菌烯醇作为全球最常见的谷物污染物，尽管其毒性比其它单端孢霉菌毒素低，却非常重要。因其对兔子的作用的资料稀缺，所以本研究旨在调查在饲喂含有高水平(10mg/kg饲料)脱氧雪腐镰刀菌烯醇的饲料后，对兔子的生产性能、血液指标、免疫指标、组织病理学改变及遗传毒性的影响。研究表明兔子对脱氧雪腐镰刀菌烯醇不敏感，但研究证实了该镰刀菌毒素能调节免疫反应。
外文摘要：As the most common grain contaminant worldwide, deoxynivalenol is of high importance despite its low toxicity compared to other trichothecene mycotoxins. Data on the effects of deoxynivalenol in rabbits are scarce. Thus, the aim of this study was to investigate the effects of dietary deoxynivalenol fed at a high level (10 mg/kg of feed) on the productive performance, blood indices, immunological variables, histopathological changes, and genotoxicity in rabbits. Forty-eight Pannon White rabbits were exposed to contaminated diets for three weeks. Despite its high concentration, deoxynivalenol did not affect the feed intake, body weight, and body weight gain. Liver and kidney function was not affected, as shown by the clinical chemistry indices. Conversely, in two rabbits the toxin caused mild fibrosis of the liver, without degenerative changes of the hepatocytes. No genotoxicity could be observed either. Gut cytokines and the phagocytic activity of the macrophages did not differ significantly. The percentage of neutrophils was significantly lower, whereas that of eosinophils was significantly higher in the toxin-fed group. Deoxynivalenol did not cause significant changes in gut and villus morphology. In 4 out of the 6 deoxynivalenol-treated animals, the ratio of lymphoblast proliferation and simultaneous apoptosis shifted towards apoptosis in the gut-associated lymphoid tissue. In the central part of the lymphoid follicles of the spleen, lymphocyte depletion and follicular atrophy could be detected. It can be concluded that rabbits are less sensitive to deoxynivalenol, but the findings confirm that this Fusarium toxin is capable of modulating the immune response.
外文关键词：Mycotoxin；immune response；histology；blood indices
作者：Kachlek, M；Szabo-Fodor, J；Szabo, A；Bors, I；Celia, C；Gerencser, Z； Matics, Z；Szendro, Z；Tuboly, T；Balogh-Zandoki, E；Glavits, R；Zotte, AD；Kovacs, M
作者单位：Kaposvar Univ
期刊名称：ACTA VETERINARIA BRNO
期刊影响因子：0.442
出版年份：2017
出版刊次：1
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