中文摘要：黄曲霉毒素B1能与氧化茶多酚络合，且小鼠对络合黄曲霉毒素B1的吸收被抑制
中文摘要：黄曲霉毒素B1是黄曲霉毒素中最普遍最致癌的形式。本报告探索了AFB1和氧化茶多酚（OTP）之间的相互作用，然后研究了OTP对小鼠体内AFB1的吸收和毒性的影响。研究证明了AFB1能够与OTP络合，而络合AFB1（C-AFB1）在小鼠体内的吸收被抑制。因此，由AFB1诱发的肝损伤可以被OTP抑制。研究结果表明了消费含OTP的产品，如发酵普洱茶可以避免AFB1损伤，而OTP也可以用作一种食品添加剂。
外文摘要：BACKGROUND Aflatoxin B1 (AFB1) is the most prevalent and carcinogenic form of the aflatoxins. In this report, we explored the interaction between AFB1 and oxidised tea polyphenols (OTP). Then, the influence of OTP on the absorption and toxicity of AFB1 in rats was investigated.
RESULTS We found that AFB1 can be complexed with OTP, and a transmembrane bidirectional transport experiment verified the absorption of complexed AFB1 (C-AFB1) was inhibited by OTP dramatically (P < 0.001). Animal experiments results showed that the AFB1 plus OTP group had significantly (P < 0.05) decreased AFB1-albumin (AFB1-alb) compared to the AFB1 group at 4 h after ingestion. OTP could significantly (P < 0.01) promote the elimination of AFB1 in faeces. Moreover, the liver injury induced by AFB1 was significantly inhibited by OTP.
CONCLUSION Our results demonstrated AFB1 can be complexed with OTP and the absorption of the C-AFB1 is inhibited in rats. Consequently, the liver injury induced by AFB1 can be inhibited by OTP. These results provide insight that consuming OTP-containing products, like fermented Pu-er tea, can protect damage from AFB1, and OTP may be used as a kind of food additive.
外文关键词：AFB1; absorption; oxidised tea polyphenols; complexed aflatoxin B1
作者：Lu, H；Liu, FF；Zhu, QQ；Zhang, MM
作者单位：Yunnan Agricultural University
期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
期刊影响因子：2.076
出版年份：2017
出版刊次：6
点击下载：黄曲霉毒素B1能与氧化茶多酚络合，且小鼠对络合黄曲霉毒素B1的吸收被抑制