中文摘要：镰刀菌毒素天然污染各种商品是一个全球性的重大问题。由于白僵菌毒素（BEA）和伏马菌素B1（FB1）在谷物中共现频繁，本研究用牛卵泡颗粒细胞(GC)评估了FB1和BEA对细胞增殖、类固醇产生和基因表达的单一和联合作用。结果表明镰刀菌毒素BEA和FB1会损害牛的生殖功能。
外文摘要：Fusarium mycotoxins are natural contaminants of various commodities representing significant problem worldwide. Since the co-occurrence of beauvericin (BEA) and fumonisin B1 (FB1) in grains is frequent, the present study was carried out to evaluate the individual and combined effects of FB1 and BEA on cell proliferation, steroid production and gene expression using bovine granulosa cells (GC). When tested alone FB1 did not show (P ≥ 0.05) effects on cell proliferation at any dose. Whereas BEA at 3, 6, and 10 μM significantly decreased (P 1 alone had no significant effect (P ≥ 0.05) on progesterone production at any tested doses, whereas FB1 at 1, 1.5 and 3 μM slightly inhibited (P 1 did not influence these effects of BEA. At 10 μM, both mycotoxins decreased (P 1 at 30 μM had no effect on CYP11A1 and CYP19A1 gene expression. Taken together these results demonstrate that the Fusarium mycotoxins BEA and FB1 may impair reproductive function in cattle.
中文关键词：Beauvericin Cattle；Fumonisin B-1；Granulosa cell；Steroidogenesis；Toxicity
外文关键词：Beauvericin Cattle；Fumonisin B-1；Granulosa cell；Steroidogenesis；Toxicity
作者：Albonico, M；Schutz, LF；Caloni, F；Cortinovis, C；Spicer, LJ
作者单位：Univ Milan
期刊名称：TOXICON
期刊影响因子：2.309
出版年份：2017
出版刊次：3
点击下载：在体外镰刀菌毒素伏马菌素B1和白僵菌毒素对牛卵泡颗粒细胞增殖和类固醇产生的影响