中文摘要：赖氨酸是水稻中最重要的氨基酸。高赖氨酸转基因水稻HFL1是通过代谢工程调节赖氨酸代谢而产生的。本文开展了90天的毒理学实验，研究目的是探讨不同剂量的HFL1水稻对SD大鼠的潜在健康影响。在试验中，作者记录了SD大鼠的体重增加量、食物消耗和食物效率等。研究发现，饲喂转基因水稻饮食（T）、非转基因水稻饮食（N）、控制饮食的SD大鼠均没有出现不良反应。另外，在中期和最终评估时，测量了SD大鼠的血液和血清化学参数，并在试验结束时检查了SD大鼠器官重量和组织病理学。研究发现，饲喂转基因水稻饮食（T）、非转基因水稻饮食（N）、控制饮食的SD大鼠在血液和血清化学参数或器官重量上无明显差异。某些参数在饲喂转基因水稻饮食（T）、非转基因水稻饮食（N）、控制饮食的SD大鼠上有差异，但没有观察到不良的组织学效应。研究结果表明，在90天含有高达70%高赖氨酸转基因水稻的饲喂试验中，高赖氨酸转基因水稻对SD大鼠没有不良影响。
外文摘要：Lysine is considered to be the first essential amino acid in rice. An elite High-Free-Lysine transgenic line HFL1 was previously produced by metabolic engineering to regulate lysine metabolism. In this study, a 90-day toxicology experiment was undertaken to investigate the potential health effect of feeding different doses of HFLI rice to Sprague-Dawley rats. During the trial, body weight gain, food consumption and food efficiency were recorded, and no adverse effect was observed in rats fed transgenic (T) rice diets compared with non-transgenic (N) or control diets. At both midterm and final assessments, hematological parameters and serum chemistry were measured, and organ weights and histopathology were examined at the end of the trial. There was no diet-related difference in most hematological or serum chemistry parameters or organ weights between rats fed the T diets and those fed the N or control diets. Some parameters were found to differ between T groups and their corresponding N and/or control groups, but no adverse histological effect was observed. Taken together, the data from the current trial demonstrates that high lysine transgenic rice led to no adverse effect in Sprague-Dawley rats given a diet containing up to 70% HFLI rice in 90 days. 
外文关键词：Transgenic rice; High free lysine; Feeding study; Toxicology; Rat
作者：Yang, Qing-Qing; He, Xiao-Yun; Wu, Hong-Yu; 等
作者单位：Yangzhou Univ
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.778
出版年份：2017
出版刊次：7
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