中文摘要：从内生真菌黑附球菌中分离出四种化合物，包括白僵菌素、对羟基苯甲醛、吲哚-3-羧酸和醌茜，并评估了其细胞毒性、抗菌及抗氧化活性。研究表明，这些化合物可用于开发富含抗氧化剂的治疗性饮食配方和作为抗细菌感染的治疗剂。
外文摘要：Four compounds including beauvericin, parahydroxybenzaldehyde, indole-3-carboxylic acid and quinizarin were isolated from endophytic fungus Epicoccum nigrum and their cytotoxicity, antibacterial and antioxidant activity were evaluated. Beauvericin had remarkable activity against two Gram-negative strains (Bacillus cereus and Salmonella typhimurium) with respective MIC values of 3.12 and 6.25 μg/ml. All the compounds had weak cytotoxic effect on both normal and tumor cells. LC50 values ranged from 40.42 to 86.56 μg/ml, 31.87 to 86.57 μg/ml and 21.59 to 67.27 μg/ml on Vero cells, THP-1 and RAW 264.7 respectively. The present study showed that these compounds could be developed for the formulation of antioxidant-rich therapeutic diets and as a therapeutic agent against bacterial infections.
外文关键词：Antimicrobial；Free radical scavenging；Cytotoxicity；Endophytic fungi；Epicoccum nigrum
作者：Dzoyem, JP；Melong, R；Tsamo, AT；Maffo, T；Kapche, DGWF；Ngadjui, BT；Mcgaw, LJ；Eloff, JN
作者单位：Univ Pretoria
期刊名称：REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
期刊影响因子：0.956
出版年份：2017
出版刊次：2
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