中文摘要：本文旨在研究膨润土（BN）改善饮食黄曲霉毒素B1（AFB1）或赭曲霉毒素A（OTA）诱导的肉鸡免疫病理学改变的作用。结果表明，饲料中添加BN有助于改善AFB1引起的免疫毒性，但不能保护OTA诱导的免疫损伤。
外文摘要：The present study was designed to investigate any ameliorative effects of bentonite (BN) against immunopathological alterations induced by dietary aflatoxin B-1 (AFB(1)) or ochratoxin A (OTA) in broiler chicks. In one experiment, AFB1 (0.1, 0.2 or 0.6mg/kg feed) was fed alone and par alley with bentonite clay (3.7 or 7.5 g/kg feed) to the broilers. In the second experiment, the broilers were given feed contaminated with OTA (0.15, 0.3 or 1.0 mg/kg feed) alone and in combination with bentonite clay (3.7, 7.5, or 15 g/kg feed). Experimental feedings were continued for 42 days. At various time points along the feeding schedule, immune system organ histologic status, as well as host humoral and cellular immune responses, were evaluated in all groups. The dietary addition of AFB(1) and OTA alone significantly reduced immune responses in the birds as assessed by histological changes in the bursa of Fabricius and thymus, antibody responses to SRBC, in-vivo lympho-proliferative responses to Phytohemagglutinin-P (PHA-P) and, phagocytic function in situ. The dietary addition of BN significantly ameliorated the immunotoxicity of 0.1 and 0.2mg/kg dietary AFB(1), however with a level of 0.6mg AFB(1)/kg only partial amelioration was seen. The co-treatment of birds exposed to OTA with BN at all levels only partially alleviated deleterious effects on histology and immune responses. Taken together, the results here suggested to us that dietary addition of BN could help ameliorate AFB(1)-mediated immunotoxicities but could not afford such protection against OTA-induced immune damage.
外文关键词：Aflatoxin B1；bentonite；immune system；ochratoxin A
作者：Bhatti, SA； Khan, MZ； Saleemi, MK； Saqib, M； Khan, A； ul-Hassan, Z
作者单位：Univ Agr Peshawar
期刊名称：JOURNAL OF IMMUNOTOXICOLOGY
期刊影响因子：2.02
出版年份：2017
出版刊次：1
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