中文摘要：本文设计、构建并测试了一种基于氧化硅/氮化硅/氧化硅波导作为偏振干涉仪的生物传感器实验装置。研究表明该装置的灵敏度相当高（特别是直接免疫分析模式下），能检测出浓度低至ppt水平的霉菌毒素。
外文摘要：A biosensor experimental set-up based on a silicon oxide/silicon nitride/silicon oxide waveguide operating as polarization interferometer was designed, built, and tested. The operation principle of the proposed sensor lies in the detection of a phase shift between p-and s-components of polarized light. The mode of operation of the proposed sensor is similar to that of Mach-Zehnder interferometer, while its design is much simpler and does not require splitting the waveguide into two arms. The refractive index sensitivity of the polarization interferometer sensor in the range of 1200 radians per refractive index unity (RIU) was evaluated. Several biosensing tests were conducted on detection of aflatoxin B1 in direct immunoassay with specific antibodies immobilized in the sensing window. Binding of 0.01 ng/ml (10 ppt) of aflatoxin B1 appeared to cause a phase shift of approximately one period. This is a remarkably high sensitivity (especially for direct immunoassay format) which the detection of mycotoxins in much lower concentrations in ppt level.
外文关键词：Planar waveguide；Polarization interferometer；Immunosensor；Direct immunoassay；Aflatoxin B1
作者：Nabok,A；Al-Jawdah,AM；Tsargorodska,A
作者单位：Sheffield Hallam Univ
期刊名称：SENSORS AND ACTUATORS B-CHEMICAL
期刊影响因子：4.758
出版年份：2017
出版刊次：10
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