中文摘要：玉米赤霉烯酮(ZEA)是由镰刀菌属的几种真菌产生的一种非甾体类真菌毒素。众所周知，它在前列腺癌细胞周期，包括癌变的调节中发挥着各种作用。本研究评估了ZEA对前列腺癌细胞的线粒体代谢、质膜透化和细胞周期的影响。根据体外研究表明，浓度分别为0.1nM、0.001nM和03nM、100 nM的ZEA可能对前列腺癌细胞增殖有促进和拮抗性能。
外文摘要：Zearalenone(ZEA) is a nonsteroidal mycotoxin produced by several fungi of the genus Fusarium spp. It is known to play various roles in the regulation of the prostate cancer cell cycle, including carcinogenesis. The present study evaluates the influence of ZEA on the mitochondrial metabolism, plasma membrane permeabilization and cell cycle of prostate cancer cells. At concentrations of 100 nM and 03 nM,ZEA caused a decrease in the oxidative activity of mitochondria, as well as increases in LDH release, apoptosis induction and the number of tells in the G0/G1 phase. The opposite effect was observed for lower concentrations (0.1 nM and 0.001 nM). These in vitro studies indicate that ZEA might have pro- and antiproliferative properties in prostate cancer cells, at concentrations 0.1 nM, 0.001 nM and 03 nM, 100 nM, respectively.
外文关键词：Mycotoxin；Zearalenone；beta-Estradiol；Prostate adenocarcinoma
作者：Kowalska,K；Habrowska-Gorczynska,DE；Dominska,K； Piastowska-Ciesielska, AW
作者单位：Med Univ Lodz
期刊名称：CHEMOSPHERE
期刊影响因子：3.698
出版年份：2017
出版刊次：180
点击下载：玉米赤霉烯酮对人前列腺癌细胞系线粒体代谢、质膜透化和细胞周期的剂量依赖性作用