中文摘要：膨润土常用作饲料添加剂，吸附胃肠道中的黄曲霉毒素，减少生物利用度，从而减轻其毒性。黄曲霉毒素是湿热地区特别有害的霉菌毒素。它们因收获前后真菌污染而出现在食物和饲料中。本研究旨在通过掺入锌（Zn）离子改良巴西膨润土，提高其吸附能力，从而持续降低黄曲霉毒素的毒性。研究表明锌改性膨润土，Zn-Bent1，代表了一种改进的防止动物饲喂AFB1污染的饲料后中毒的工具。
外文摘要：Bentonites are commonly used as feed additives to reduce the bioavailability and thus the toxicity of aflatoxins by adsorbing the toxins in the gastrointestinal tract. Aflatoxins are particular harmful mycotoxins mainly found in areas with hot and humid climates. They occur in food and feedstuff as a result of fungal contamination before and after harvest. The aim of this study was to modify Brazilian bentonite clay by incorporation of zinc (Zn) ions in order to increase the adsorption capacity and consequently reduce the toxicity of aflatoxins. The significance of Zn intercalating conditions such as concentration, temperature and reaction time were investigated. Our results showed that the Zn treatment of the bentonite increased the aflatoxin B-1 (AFB(1)) adsorption and that Zn concentration had a negative effect. Indeed, temperature and time had no significant effect in the binding capacity. The modified bentonite (Zn-Bent1) was not cytotoxic to either fibroblasts (3T3) nor epithelial colorectal adenocarcinoma cells (Caco-2) cell lines. Interestingly, Zn-Bent1 has higher protective effect against AFB(1) induced cytotoxicity than the unmodified bentonite. In conclusion, the Zn modified bentonite, Zn-Bent1, represent an improved tool to prevent aflatoxicosis in animals fed on AFB(1) contaminated feed.
外文关键词：Bentonite；Zinc；Aflatoxin B-1；Fibroblasts；Colon carcinoma cells
作者：Nones, J；Solhaug, A；Eriksen, GS；Macuvele, DLP；Poli, A；Soares, C；Trentin, AG；Riella, HG；Nones, J
作者单位：Univ Fed Santa Catarina
期刊名称：JOURNAL OF HAZARDOUS MATERIALS
期刊影响因子：4.836
出版年份：2017
出版刊次：9
点击下载：锌改性膨润土提高黄曲霉毒素B1吸附性并提高成纤维细胞（3T3）和上皮性大肠腺癌细胞(Caco-2)的存活率