中文摘要：慢性乙型肝炎病毒携带者(HBV)的黄曲霉毒素B1(AFB1)与肝硬化间的关系尚无定论。本文在大型社区队列内进行病例对照研究，旨在评估AFB1暴露对慢性HBV携带者肝硬化和HCC的影响。结果表明AFB1以剂量依赖方式增加慢性HBV携带者的肝硬化及HCC风险。
外文摘要：The relation between aflatoxin B1 (AFB1) and cirrhosis in chronic carriers of hepatitis B virus (HBV) remains inconclusive. This case-control study nested in a large community-based cohort aimed to assess the effect of AFB1 exposure on cirrhosis and HCC in chronic HBV carriers. Serum AFB1-albumin adduct levels at study entry were measured in 232 cirrhosis cases, 262 HCC cases and 577 controls. Multivariate-adjusted odds ratios (aORs) and 95% confidence intervals (95% CIs) were estimated using logistic regression. Among all chronic HBV carriers, the time intervals between study entry and diagnosis of HCC, cirrhosis, cirrhotic HCC, and non-cirrhotic HCC were all significantly (p1-albumin adducts than those with low/undetectable levels. There were significant dose-response relations with serum AFB1-albumin adduct level at study entry for cirrhosis (p-trend=0.0001) and cirrhotic HCC (p-trend1-albumin adduct levels were 2.45 (1.51-3.98) for cirrhosis (p=0.0003), 5.47 (2.20-13.63) for cirrhotic HCC (p=0.0003), and 5.39 (1.11-26.18) for non-cirrhotic (p=0.0368) HCC, respectively. There remained a significant dose-response relation between serum AFB1-albumin adduct level and HCC risk (p-trend=0.0291) in cirrhosis patients, showing an aOR (95% CI) of 3.04 (1.11-8.30) for high vs. undetectable serum levels (p=0.0299). It is concluded that AFB1 exposure may increase the risk of cirrhosis and HCC in a dose-response manner among chronic HBV carriers.
外文关键词：aflatoxin B-1-albumin adducts；cirrhosis；HCC；chronic hepatitis B
作者：Chu, YJ；Yang, HI；Wu, HC；Liu, J；Wang, LY；Lu, SN；Lee, MH；Jen, CL；You, SL；Santella, RM；Chen, CJ
作者单位：Natl Yang Ming Univ
期刊名称：INTERNATIONAL JOURNAL OF CANCER
期刊影响因子：5.531
出版年份：2017
出版刊次：4
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