中文摘要：为了评估水合钠钙硅酸铝（HSCAS）在饲喂了黄曲霉毒素（AFB1）的猪体内的功效，本研究测定了血清AFB1-赖氨酸。研究发现可以用AFB1-赖氨酸作为诊断AFB1的特异性生物标志物，并用于评估猪的化学保护干预措施。
外文摘要：In this study, serum aflatoxin B1 (AFB1)-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB1. Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water. A completely randomized design was used with six animals assigned to each of four dietary treatments for 21 days as follows: (A) basal diet (BD), (B) BD supplemented with 0.5 % HSCAS, (C) BD supplemented with 1.1 mg/kg AFB1, and (D) BD supplemented with 0.5 % HSCAS and 1.1 mg/kg AFB1. HSCAS was able to alleviate the toxic effects of AFB1 on pigs and reduce (P 1-lysine. Cumulative reductions of adduct yield values, calculated through the equation [(pg AFB1-lysine/mg albumin) / (μg AFB1/kg body weight)], were 53.0, 62.8, and 72.1 after 7, 14, and 21 days of oral exposure, respectively. AFB1-lysine has potential as an AFB1-specific biomarker for diagnostic purposes and for evaluating the efficacy of chemoprotective interventions in pigs.
外文关键词：AFB(1)-lysine adduct；LC-MS/MS；Adsorbent；Swine
作者：Di Gregorio, MC；Jager, AV；Souto, PCMC；Costa, AA；Rottinghaus, GE；Passarelli, D；Budino, FEL；Corassin, CH；Oliveira, CAF
作者单位：Univ Sao Paulo
期刊名称：MYCOTOXIN RESEARCH
期刊影响因子：2.0
出版年份：2017
出版刊次：2
点击下载：测定饲喂了黄曲霉毒素B1污染饲料的猪血清中的黄曲霉毒素B1-赖氨酸，评估一种吸附黄曲霉毒素的饲料添加剂的功效