中文摘要：黄曲霉毒素污染动物饲料会损伤动物健康及生产性能。本文旨在研究饲料中香豆素和/或叶绿素防止小鼠黄曲霉毒素中毒的作用。结果表明叶绿素和香豆素有保护小鼠黄曲霉毒素中毒及抗癌的作用。
外文摘要：Aflatoxin contamination of animal diet has adverse effects on animal health and productivity. This study was performed to investigate the effect of using coumarin and/or chlorophyllin in rat diet against aflatoxicosis. Fifty-four rats were assigned into 7 groups (6 rats each). G1 was a negative control. G2 received water with coumarin 0.5%. G3 received water with chlorophyllin 0.5%. G4 received water with coumarin 0.5% and chlorophyllin 0.5%. G5-8 fed aflatoxin B1 1000 ppb in diet. Group 6–8 were administered similar treatments as G2-4. The experiment ended after 8 weeks. Random glucose, total lipid, total cholesterol, total triglycerides, total protein, serum ALT, AST, creatinine, and urea were measured. Histopathology of liver, kidney and pancreas and immunohistochemical staining of placental glutathione-S-transferase (GST-P) in liver were performed. The glucose serum level, cholesterol, AST, and ALT were elevated in G5 compared to G6-8. The liver and kidney lesions in G5 included vacuolation and necrosis which subsided in G6-8. The necrosis and inflammatory cells infiltration in the pancreas of G5 were absent in G6-8. GST-P positive hepatocytes were abundant in G5, few in G6 and absent in G7 and G8. In conclusion, the chlorophyllin and coumarin possessed protective and anti-carcinogenic effect against aflatoxicosis in rats.
外文关键词：Aflatoxin；Coumarin；Chlorophyllin；Immunohistochemistry；Placental glutathione-S-transferase
作者：Abdel-Latif, MS；Elmeleigy, KM；Aly, TAA；Khattab, MS；Mohamed, SM
作者单位：Cairo Univ
期刊名称：EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
期刊影响因子：1.716
出版年份：2017
出版刊次：5
点击下载：小鼠体内香豆素和叶绿素抗黄曲霉毒素中毒的病理生化评价