中文摘要：为了弄清黄曲霉毒素对生长性能及体液免疫和粘膜免疫的作用，将240只1日龄小鸡分成相等的4组。处理组包括组1：以玉米和大豆为标准日粮的阴性对照，组2：基础日粮添加3ppm黄曲霉毒素的阳性对照，组3：基础日粮添加0.25%的霉可脱(R)和组4：日粮中添加0.25%的霉可脱(R)和3ppm黄曲霉毒素，从孵化开始持续28天。结果表明，黄曲霉毒素对上呼吸道粘膜免疫及生长性能和体液免疫应答有影响。在黄曲霉毒素污染的日粮中补充霉可脱(R)，能降低黄曲霉毒素对生长性能及粘膜免疫和系统免疫应答的不良反应。
外文摘要：To determine the aflatoxin effect on performance, and humoral and mucosal immunity, 240 one-day old chicks were divided into 4 equal groups. Treatment groups include Group 1: chickens that received a standard diet based on corn and soy as negative control, Group 2: chickens fed with a basal diet containing 3 ppm aflatoxin as positive control, Group 3: chickens fed with 0.25% Mycoad (R) in basal diet, and Group 4: chickens fed with diet containing 0.25% Mycoad (R) plus 3 ppm aflatoxin. All chickens continuously received diets from hatching until 28 days old. Growth indices, such as weight gain, feed consumption and food conversion rate, were determined weekly. At 28 days, all chickens were sacrificed. After blood sampling, serum was prepared to measure serum IgG titer against Newcastle disease vaccine using the HI method. Moreover, the heads were collected for nasal-tracheal lavage for assaying IgA against infectious bronchitis vaccine in the mucosa of the respiratory tract. The measurement of mucosal IgA was carried out using the ELISA method with specific goat anti-chicken IgA. That results indicated that chickens that received aflatoxin demonstrated lower growth indices, and fewer serum IgG and mucosal IgA titers than others did, while performance and immune responses in chickens that received Mycoad (R) plus aflatoxin were significantly higher than chickens fed with aflatoxin alone. Overall, it seems that aflatoxin can affect mucosal immunity in the upper respiratory tract as well as performance and humoral immune responses. Supplementation of Mycoad (R) to diet contaminated with aflatoxin can reduce the adverse effects of aflatoxin on performance, as well as mucosal and systemic immune responses.
外文关键词：aflatoxin；chicken；immunity；Mycoad (R)
作者：Amiri, M；Gholami-Ahangaran, M；Jafarian-Dehkordi, M
作者单位：Islamic Azad Univ
期刊名称：SLOVENIAN VETERINARY RESEARCH
期刊影响因子：0.091
出版年份：2017
出版刊次：1
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