中文摘要：黄曲霉毒素对于以栽培谷物为主要动物饲料和人类营养的食品经济来说是一个严重的问题。本研究目的有二：第一，评估新合成的缩氨基硫脲混合物作为抗真菌和抗毒素制剂的活性；第二，用一系列不同端点的测试研究其毒性及遗传毒性危害。本文初步分析了两种分子：S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazone，及其金属络合物bis(S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazonato)nickel (II)。对抑制真菌生长及产生黄曲霉毒素的分析结果表明，两种分子都具有良好的抗真菌活性，对细菌没有致突变作用。分析确定化合物对人体细胞没有不良影响，但它们具有细胞毒性，在与镍化合后也具有遗传毒性。
外文摘要：Aflatoxins represent a serious problem for a food economy based on cereal cultivations used to fodder animal and for human nutrition. The aims of our work are two-fold: first, to perform an evaluation of the activity of newly synthesized thiosemicarbazone compounds as antifungal and anti-mycotoxin agents and, second, to conduct studies on the toxic and genotoxic hazard potentials with a battery of tests with different endpoints. In this paper we report an initial study on two molecules: S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazone and its metal complex, bis(S-4-isopropenylcyclohexen-1-carbaldehydethiosemicarbazonato)nickel (II). The outcome of the assays on fungi growth and aflatoxin production inhibition show that both molecules possess good antifungal activities, without inducing mutagenic effects on bacteria. From the assays to ascertain that the compounds have no adverse effects on human cells, we have found that they are cytotoxic and, in the case of the nickel compound, they also present genotoxic effects.
外文关键词：Aflatoxins；Metal complexes；Antifungal activity；Toxicity；Genotoxicity
作者：Zani, C；Bisceglie, F；Restivo, FM；Feretti, D；Pioli, M；Degola, F；Montalbano, S；Galati, S；Pelosi, G；Viola, GVC；Carcelli, M；Rogolino,　D；Ceretti, E；Buschini, A
作者单位：Univ Brescia
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.584
出版年份：2017
出版刊次：7
点击下载：由多种试验组成的综合方法评估真菌和毒素抑制特性及细胞毒性/基因毒性副作用，优化筛选缩氨基硫脲类化合物