中文摘要：在众多的挑战中，黄曲霉毒素，特别是黄曲霉毒素B1（AFB1）暴露，是家禽业的主要问题之一。AFB1中毒导致肉/蛋产量下降、肝毒性、肾毒性、胃肠道功能紊乱（GIT）和繁殖、免疫抑制并增加疾病易感性。在饲粮中补充硒（Se）和锌（Zn）提供了简便、经济有效的方法来中和AFB1的毒性作用。本研究讨论了AFB1对家禽业的影响，它的生物转化和器官特异性毒性作用，以及AFB1诱导的毒性作用机理。此外，还阐明了Se和Zn在禽类中的生物和解毒作用以及这两种微量元素的保护机制。最终，讨论了补充硒和锌对AFB1诱导的家禽毒性的改善作用。
外文摘要：Among many challenges, exposure to aflatoxins, particularly aflatoxin B1 (AFB1), is one of the major concerns in poultry industry. AFB1 intoxication results in decreased meat/egg production, hepatotoxicity, nephrotoxicity, disturbance in gastrointestinal tract (GIT) and reproduction, immune suppression, and increased disease susceptibility. Selenium (Se) and zinc (Zn), in dietary supplementation, offer easy, cost-effective, and efficient ways to neutralize the toxic effect of AFB1. In the current review, we discussed the impact of AFB1 on poultry industry, its biotransformation, and organ-specific noxious effects, along with the action mechanism of AFB1-induced toxicity. Moreover, we explained the biological and detoxifying roles of Se and Zn in avian species as well as the protection mechanism of these two trace elements. Ultimately, we discussed the use of Se and Zn supplementation against AFB1-induced toxicity in poultry birds.
外文关键词：Aflatoxin B1；Detoxification；Se；Zinc；Supplementation；Poultry
作者：Mughal, MJ；Peng, X；Kamboh, AA；Zhou, Y；Fang, J
作者单位：Sichuan Agr Univ
期刊名称：BIOLOGICAL TRACE ELEMENT RESEARCH
期刊影响因子：1.798
出版年份：2017
出版刊次：2
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