中文摘要：本研究分别用含有3.1、6.1或9.0mu g FB1/g日粮饲喂24头小猪28天，然后用色谱-质谱联用(LC-MS/MS)测定了血浆、尿液、粪便及毛发中的伏马菌素B1（FB1）的残留量。研究发现虽然建议用血浆评估长时间(>14天)暴露，但它和尿液FB1也是猪低水平FB1日粮早期暴露的良好生物标志物；还确定了以评估毛发作为伏马菌素暴露的生物标志物的可能性，当然还需进一步研究猪毛发中基于生理学的残留FB1毒代动力学。
外文摘要：The levels of fumonisin B-1 (FBI) residues in plasma, urine, feces and hair from 24 piglets fed FB1-contaminated diets containing 3.1, 6.1 or 9.0 mu g FB1.g(-1) for 28 days were determined using liquid chromatography coupled to mass spectrometry (LC-MS/MS). The levels of FB1 in plasma, urine, feces and pooled hair (n = 3) samples varied from 0.15 to 1.08 mu g.L-1, 16.09-75.01 mu g.L-1, 1.87-13.89 mu g.g(-1) and 2.08-8.09 ng.g(-1), respectively. Significant correlations (r = 0.808-0.885; P < 0.001; N = 18) were found between FB1 intake and plasma FB1 on days 7, 14, 21 and 28. However, urinary FB1 correlated with FB1 intake only on days 7 and 14 (r = 0.561-572; P = 0.02; N = 18). A significant correlation (r = 0.509; P = 0.02; N = 24) was also found for the first time between FB1 in hair samples and FB1 intake. Plasma and urinary FB1 are good biomarkers of early exposure of pigs to low dietary FB1 levels, although plasma is recommended to assess prolonged exposure (>14 days). The possibility to evaluate hair as a biomarker of fumonisin exposure was established, although further studies are needed to provide physiologically based toxicokinetics of residual FB1 in the pig hair.
外文关键词： FB1; Plasma; Urine; Hair; Biomarker; Exposure assessment
作者：Souto, PCMC；Jager, AV；Tonin, FG；Petta, T；Di Gregorio, MC；Cossalter, AM；Pinton, P；Oswald, IP；Rottinghaus, GE；Oliveira, CAF；AF Souto, Pollyana C. M. C.；Jager, Alessandra V.；Tonin, Fernando G.；Petta, Tania
作者单位：Univ Sao Paulo
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.584
出版年份：2017
出版刊次：-
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