中文摘要：欧洲食品安全局作为欧洲负责转基因作物安全性评价的监管机构，认为被量化为转基因作物（如大豆）组成部分的内源性过敏原是主要的过敏食物。这一食品安全的评估结果受到多种原因的质疑，包括与传统育种相比细微的过敏原水平改变。非转基因大豆、转基因大豆及同期种植的非转基因商业参考大豆的散点图对比发现，转基因大豆对内源性过敏原的影响要低于传统育种。
外文摘要：The regulatory body that oversees the safety assessment of genetically modified (GM) crops in the European Union, the European Food Safety Authority (EFSA), uniquely requires that endogenous allergen levels be quantified as part of the compositional characterization of GM versions of crops, such as soybean, that are considered to be major allergenic foods. The value of this requirement for assessing food safety has been challenged for multiple reasons including negligible risk of altering allergen levels compared with traditional non-GM breeding. Scatter plots comparing the mean endogenous allergen levels in non-GM soybean isoline grain with the respective levels in GM grain or concurrently grown non-GM commercial reference varieties clearly show that transgenesis causes less change compared with traditional breeding. This visual assessment is confirmed by the quantitative fit of the line of identity (y = x) to the datasets. The current science on allergy does not support the requirement for quantifying allergen levels in GM crops to support safety assessment.
外文关键词：Surrogate peptide; Multiplexing method; Method validation; Endogenous allergens; Soybean; Genetically engineered; LC-MS/MS; Mass spectrometry; Food safety; Glycine max
作者：Hill, Ryan C.; Fast, Brandon J.; Herman, Rod A.
作者单位：Dow AgroSci LLC
期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY
期刊影响因子：2.221
出版年份：2017
出版刊次：10
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