中文摘要：本研究旨在探索受黄曲霉毒素污染的日粮中，酵母细胞壁、硅酸铝及某些益生菌菌株对肉鸡GOT2、CYP450 1A5基因的表达及肝酶，包括GGT、ALT、AST和LDH的血清浓度的影响。结果表明，接受了黄曲霉毒素吸附化合物的实验组减少了由黄曲霉毒素提高CYP450 1A5表达的不良反应。
外文摘要：This study was conducted to investigate the effect of cell wall yeast, aluminosilicate and some probiotic strains in diets contaminated with aflatoxin, on the expression of GOT2, CYP450 1A5 genes and serum concentrations of liver enzymes including GGT, ALT, AST and LDH in broilers. 400 seven-days old chicks from strain Cobb 500 were used as a completely randomized design with 8 treatments, 5 replications. Treatments were included: 1-Negative control (NC), 2-NC + 1 mg/kg aflatoxin or positive control (PC), 3-PC + 1 kg/ton Toxeat (R) (a toxin binder), 4-PC + Lactobacillus strains (L), 5-PC + Bacillus subtilis JQ(618) strain (B), 6-PC + Saccharomyces cerevisiae's cell wall (Y), 7-PC + [ PC+ BLY) B+ L+ Y(], 8-PC + Hydrated sodium calcium Aluminosilicate (HA). The serum concentrations of LDH, ALT, GGT and AST were increased in PC group at 42d (P < 0.05). Tox (R), L and BLY reduced serum levels of AST (P < 0.05). Increased serum concentration of GGT was observed in PC treatment, decreased by HA, Y, B and L treatments (P < 0.05). The results showed the upregulation of GOT2, CYP450 1A5 in PC group. But Y, B, L and Tox (R) reduced the expression of GOT2. The groups receiving aflatoxin adsorbent compounds reduced the adverse effects of aflatoxin on increasing the expression of CYP450 1A5.
外文关键词：Aflatoxin；Broiler Chickens；Gene Expression；Liver Enzymes；Probiotic strains；Toxeat (R)
作者：Barati, M；Chamani, M；Mousavi, SN；Hoseini, SA；Ebrahimi, MTA；AF Barati, Mohsen；Chamani, Mohammad；Mousavi, Seyed Naser；Hoseini, Seyed Abdollah；Ebrahimi, Maryam Taj Abadi
作者单位：Islamic Azad Univ, Sci & Res Branch
期刊名称：KAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISI
期刊影响因子：0.418
出版年份：2017
出版刊次：6
点击下载：黄曲霉毒素污染的日粮中，商业毒素粘合剂、天然益生菌、酵母细胞壁及硅酸铝对肉鸡GOT2、CYP450 1A5基因的表达及肝酶血清浓度的影响