中文摘要：黄曲霉毒素B1（AFB1）是毒性最强的黄曲霉毒素，其主要代谢物黄曲霉毒素M1（AFM1），频繁出现在哺乳期妇女的乳汁中。本研究旨在评估有关黎巴嫩哺乳期妇女乳汁AFM1污染的发生及因素。结果表明，虽然AFM1污染发生率很低，但本创新性研究也强调了开展对母乳中霉菌毒素污染的调查及研发避免婴儿受该强化学危害物暴露的保护措施的重要性。
外文摘要：Aflatoxin B-1 (AFB(1)) is the most potent of the dietary aflatoxins, and its major metabolite, aflatoxin M-1 (AFM(1)), is frequently found in the breast milk of lactating mothers. The aim of this study was to assess the occurrence and factors associated with AFM(1) contamination of breast milk collected from lactating mothers in Lebanon. A total of 111 breast milk samples were collected according to the guidelines set by the World Health Organization. Samples were analyzed with a competitive enzyme linked immunosorbent assay between December 2015 and November 2016. A survey was used to determine the demographic and anthropometric characteristics of participating lactating mothers. Dietary habits were assessed using a semiquantitative food frequency questionnaire. Mean (+/-standard deviation) concentration of AFM(1) in the breast milk samples was 4.31 +/- 1.8 ng/L, and 93.8% of samples contained AFM(1) at 0.2 to 7.9 ng/L. The mean concentration of AFM(1) was significantly lower (P < 0.05) in fall and winter (4.1 +/- 1.9 ng/L) than in spring and summer (5.0 +/- 1.7 ng/L). None of the samples exceeded the European Commission regulation limit (25 ng/L) for infant milk replacement formula. AFM(1) contamination was significantly associated (P < 0.05) with the daily consumption of white cheeses but not with the consumption of meat or cereal products. No significant association (P > 0.05) was observed between AFM(1) concentrations in breast milk and anthropometric sociodemographic factors (age and level of education) or the governorate of residence of the nursing mothers. The mean AFM(1) estimated daily intake was found to be 0.69 ng/day/kg of body weight. Although the incidence of AFM(1) contamination was low, our first-of-its-kind study highlights the importance of conducting investigations on mycotoxin contamination in breast milk and of developing protection strategies to tackle the exposure of infants to this potent chemical hazard.
外文关键词：Aflatoxin M-1；Breast milk；Determinants；Lebanon；Nutrition
作者：Elaridi, J；Bassil, M；Kharma, JA；Daou, F；Hassan, HF；AF Elaridi, Jomana；Bassil, Maya；Kharma, Joelle Abi；Daou, Farah；Hassan, Hussein F.
作者单位：Lebanese Amer Univ
期刊名称：JOURNAL OF FOOD PROTECTION
期刊影响因子：1.609
出版年份：2017
出版刊次：10
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