中文摘要：富勒醇在不同领域使用的增加及预期的环境蔓延的扩大要求必须测试富勒醇纳米颗粒(FNP)对微生物群的影响。尽管FNP具有改变霉菌毒素产生的巨大潜力，但是关于产毒真菌与FNP间相互作用的信息却很少。即，FNP同时具有ROS-猝灭和ROS-产生的性质，而氧化应激则能刺激真菌合成真菌毒素。为了阐明FNP与产毒真菌相互作用的程度，本研究在黄曲霉产毒菌株(NRRL 3251)用液体培养基温育168小时的过程中，研究了富勒醇C60(OH)24纳米颗粒（10,100,1000ng / mL）对菌丝生长、黄毒产生及氧化应激调节的作用。这些发现有助于评估富勒醇的环境风险和应用潜力。
外文摘要：Increased use of fullerols in various fields and expected increase of their environmental spread impose the necessity for testing fullerol nanoparticles (FNP) effects on microbiota. There is little information available on the interaction of mycotoxigenic fungi and FNP, despite FNP having a great potential of modifying mycotoxin production. Namely, FNP exhibit both ROS-quenching and ROS-producing properties, while oxidative stress stimulates mycotoxin synthesis in the fungi. In order to shed some light on the extent of interaction between FNP and mycotoxigenic fungi, the effects of fullerol C60(OH)24 nanoparticles (10, 100, 1000 ng/mL) on mycelial growth, aflatoxin production and oxidative stress modulation in an aflatoxigenic strain of Aspergillus flavus (NRRL 3251) during 168 h of incubation in a liquid culture medium were examined. FNP slightly reduced mycelial biomass weight, but significantly decreased aflatoxin concentration in media. Lipid peroxide content, superoxide dismutase, catalase and glutathione peroxidase activities suggest that FNP treatments hormetically reduced oxidative stress within fungal cells in turn suppressing aflatoxin production. These findings contribute to the assessment of environmental risk and application potential of fullerols.
外文关键词：Fullerol C-60(OH)(24)；Nanoparticles；Aspergillus flavus；Mycelial growth；Aflatoxin production；Oxidative stress
作者：Kovac, T；Sarkanj, B；Klapec, T；Borisev, I；Kovac, M；Nevistic, A；Strelec, I
作者单位：Josip Juraj Strossmayer Univ Osijek
期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
期刊影响因子：2.76
出版年份：2017
出版刊次：20
点击下载：富勒醇C-60(OH)(24)纳米颗粒和产真菌毒素真菌：调节霉菌毒素产生的初步研究