中文摘要：人们通常采用气相色谱法、液相色谱法、质谱联用技术或酶联免疫吸附试验（ELISA）等技术进行霉菌毒素检测，但这些方法费时费力、需要大型的仪器和熟练的技术人员且消耗大量危险的试剂和溶剂，而微流控芯片技术在消耗较少的样本和较短的时间内，便可实现样品的集成化、小型化和高通量检测，因此，微流控芯片检测可以弥补传统检测技术的不足。本文综述了微流控芯片技术在食品真菌毒素检测中的应用，首先介绍了真菌毒素的毒性和微流控芯片的材料，然后详细描述了集成了各种检测方法（光学、电化学、光电电化学和无标记检测）的微型芯片在检测真菌毒素方面的应用，最后对微流控芯片技术在真菌毒素检测方面所面临的挑战和未来进行了展望。
外文摘要：Mycotoxins are one of the main factors impacting food safety. Mycotoxin contamination has threatened the health of humans and animals. Conventional methods for the detection of mycotoxins are gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS), or enzyme-linked immunosorbent assay (ELISA). However, all these methods are time-consuming, require large-scale instruments and skilled technicians, and consume large amounts of hazardous regents and solvents. Interestingly, a microchip requires less sample consumption and short analysis time, and can realize the integration, miniaturization, and high-throughput detection of the samples. Hence, the application of a microchip for the detection of mycotoxins can make up for the deficiency of the conventional detection methods. This review focuses on the application of a microchip to detect mycotoxins in foods. The toxicities of mycotoxins and the materials of the microchip are firstly summarized in turn. Then the application of a microchip that integrates various kinds of detection methods (optical, electrochemical, photo-electrochemical, and label-free detection) to detect mycotoxins is reviewed in detail. Finally, challenges and future research directions in the development of a microchip to detect mycotoxins are previewed.
外文关键词：mycotoxin, microchip, microfluidic, microarray
作者：Man, Yan; Liang, Gang; Li, An; Pan, Ligang
作者单位：Beijing Acad Agr & Forestry Sci, Beijing Res Ctr Agr Stand & Testing, Beijing 100097, Peoples R China.
期刊名称：TOXINS
期刊影响因子：3.03
出版年份：2017
出版刊次：10
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