中文摘要：本研究的目的是检测常用农药（嘧菌酯、噻嗪酮、氯虫苯甲酰胺、苯醚甲环唑、氟虫腈、吡虫啉、稻瘟灵、丙草胺、丙环唑、戊唑醇、三环唑、吡蚜酮、和肟菌酯）在空气中的浓度以及对稻田农民的健康风险。本文选取来自马来西亚雪兰莪州丹绒加弄市的83位农民，使用夹子将固体吸附管固定在农夫的呼吸区域，收集呼吸样本。通过丙酮提取、离心、氮排污浓缩来收集XAD-2树脂中的农药，采用1 mL超纯水/高效液相色谱级3:1的甲醇溶液进行重组，最后通过超高效液相色谱-串联质谱法进行分析。目标分析物中浓度最高的是氟虫腈残留，达到462.5 ng/m3，但危险商数小于1，危险指数值为3.86×10-3，表明农药残留与健康风险相关性不显著，对吡蚜酮引起的癌症发病风险（LCR）为4.10 x 10-8，也在可接受范围内(LCR < 10(-6))。该研究有助于农业地区农民健康风险管理。
 
外文摘要：Tanjung Karang, Selangor, is widely known for its paddy cultivation activity and hosts the third largest paddy field in Malaysia. Pesticides contamination in agriculture fields has become an unavoidable problem, as pesticides are used to increase paddy productivity and reduce plant disease. Human exposure to agrichemicals is common and could results in both acute and chronic health effects, such as acute and chronic neurotoxicity. This study aims to determine the concentrations of commonly used pesticides (azoxystrobin, buprofezin, chlorantraniliprole, difenoconazole, fipronil, imidacloprid, isoprothiolane, pretilachlor, propiconazole, pymetrozine, tebuconazole, tricyclazole, and trifloxystrobin) in personal air samples and their associated health risks among paddy farmers. Eighty-three farmers from Tangjung Karang, Selangor were involved in this study. A solid sorbent tube was attached to the farmer's breathing zone with a clip, and an air pump was fastened to the belt to collect personal air samples. Pesticides collected in the XAD-2 resin were extracted with acetone, centrifuged, concentrated via nitrogen blowdown and reconstituted with 1 mL of 3:1 ultrapure water/HPLC-grade methanol solution. The extract was analyzed using ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). The target compounds were detected with a maximum concentration reaching up to 462.5 ng m(-3) (fipronil). The hazard quotient (HQ) was less than 1 and the hazard index (HI) value was 3.86 x 10(-3), indicating that the risk of pesticides related diseases was not significant. The lifetime cancer risk (LCR) for pymetrozine was at an acceptable level (LCR < 10(-6)) with 4.10 x 10(-8). The results reported in this study can be beneficial in terms of risk management within the agricultural community. (C) 2017 Elsevier B.V. All rights reserved.
外文关键词：Inhalation, Malaysia, Ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS), Hazard quotient (HQ), Lifetime cancer risk (LCR), Multiple reaction monitoring (MRM)
作者：Hamsan, Hazwanee; Ho, Yu Bin; Zaidon, Siti Zulfa; Hashim, Zailina; Saari, Nazamid; Karami, Ali
作者单位：Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Environm & Occupat Hlth, Upm Serdang 43400, Selangor, Malaysia.
期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT
期刊影响因子：4.9
出版年份：2017
出版刊次：12
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