中文摘要：本文通过为期90天的喂养实验，旨在对富含β胡萝卜素转基因水稻EH的膳食安全性进行评估。研究设置两个实验组和一个对照组，分别对SD大鼠饲喂含有45%的中华稻米粉11的饲料、含有45%的富含β胡萝卜素的转基因水稻EH的饲料、标准饲料。在试验期间，每周对每只老鼠称重和摄食两次，并每天观察他们的行为。最后，从麻醉大鼠中获取血液样本，测量血液学和血清化学指标，并对各组的生长性能、解剖及病理进行分析。研究发现，三组虽然有几个参数在统计学上有显著差异，但在大鼠年龄和品种的正常参考范围内。因此，这些变化被认为与饮食无关。研究结果表明，富含β胡萝卜素的转基因水稻EH与中华11稻米相比，在生物学上没有意想不到的效果。
外文摘要：This 90-day study aimed to assess the dietary safety of transgenic rice EH which is rich in beta-carotene. Two experimental groups of Sprague-Dawley rats were fed diets containing 45% rice flour of Zhonghua 11 rice and transgenic rice EH rich in beta-carotene, respectively. The reference group was fed a diet containing standard feed nutrition. During the trial period, each rat was weighed and the food intake was recorded twice a week. Their behaviors were observed daily. In the end, blood samples were obtained from all anesthetized rats to measure the hematologic and serum chemistry indicators. Growth performance, anatomy and pathology of all organs in each group were analyzed. Although a few parameters were found to be statistically significantly different across groups, they were within the normal reference range for this breed and age of rats. Therefore, the changes were not considered to be diet related. The results revealed that the transgenic rice EH rich in beta-carotene was as nutritious as Zhonghua 11 rice and showed a lack of biologically meaningful unintended effects. 
外文关键词：B-carotene; Food safety assessment; EH rice; Transgenic rice; Toxicity assessment
作者：Wu, Yangyang; Xu, Yan; Du, Yanan; 等.
作者单位：Shanghai Acad Agr Sci
期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY
期刊影响因子：2.221
出版年份：2017
出版刊次：8
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