中文摘要：本文通过90天的亚慢性毒性研究，进行了转基因耐除草剂das-44406-6大豆与四种非转基因大豆的安全性评价。作者对大鼠进行了笼边和手持式临床观察、眼部检查、体重/体重增长、饲料消耗量、血常规、凝血酶原时间、尿常规、生化、脏器重量和组织病理学病理检查等。研究发现，在90天的大鼠饮食管理中，转基因das-44406-6大豆饮食没有造成任何与治疗相关的副作用。
外文摘要：A 90-day sub chronic toxicity study was conducted in rats to evaluate the safety of genetically modified DAS-44406-6 soybeans expressing herbicide tolerant proteins when compared with its conventional comparators (non-transgenic near isoline control soybean and three commercially available non-transgenic line control soybeans). Rats were given diets formulated with either 10% or 20% w/w of soybean meal and 1% or 2% hulls of DAS-44406-6 soybean with an equivalent amount of hulls from an isoline non-transgenic control soybean for at least 90 days. In addition, three separate 20% w/w non-transgenic commercially available soybean varieties were also given to groups of rats to serve as reference controls. Animals were evaluated by cage-side and hand-held detailed clinical observations, ophthalmic examinations, body weights/body weight gains, feed consumption, hematology, prothrombin time, urinalysis, clinical chemistry, selected organ weights, and gross and histopathologic examinations. Under the conditions of this study, the genetically modified DAS-44406-6 diets did not cause any treatment-related effects in rats following 90 days of dietary administration as compared with rats fed diets with soybean of isoline control or commercial reference controls and are considered equivalent to the diets prepared from conventional comparators.
外文关键词：DAS-44406-6; Genetically-modified soybean; Subchronic rat; Transgenic soybean; Herbicide tolerant; Aryloxyalkanoate dioxygenase
作者：Papineni, Sabitha; Murray, Jennifer A.; Ricardo, Ekmay; 等.
作者单位：Dow AgroSci LLC
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.778
出版年份：2017
出版刊次：11
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