中文摘要：为评估抗草甘膦转基因大豆的安全性，本文用含转基因大豆GTS40-3-2和非转基因亲本大豆A5403的饲料对第一代和第二代（SD）大鼠进行了为期195天的喂养实验。其中，大豆占饲料总重量的20%。作者每周监测大鼠的体重、食物消耗、血液学、血液生化和病理学观察等指标。结果发现，各组大鼠生长发育状况都很好，尽管各组大鼠脏器重量比值和血清生化指标有显著差异，但差异在正常范围内均无生物学意义。研究结果表明，抗草甘膦转基因大豆GTS40-3-2与非转基因亲本大豆A5403在长期SD大鼠喂养试验中安全性相当。本研究为转基因大豆GTS40-3-2的安全使用提供了有力的实验依据。
外文摘要：To assess the safety of glyphosate-resistant transgenic soybean, the transgenic soybean GTS40-3-2 meal and its non-transgenic counterpart parent A5403 were fed to first-and second-generation Sprague-Dawley (SD) rats (Rattus norvegicus) for 1 95 days. The soybean meal made up 20% of the total weight of the feed. Body weight, food consumption, hematology, blood biochemistry, and pathological observations were monitored weekly. The results showed that rats of each group experienced good growth and development, and although results of some organ weight ratios and serum biochemistry between the groups were significantly different (P<0.05), they were of no biological significance because the variations were within the normal range. These results indicate that glyphosate-resistant transgenic soybean GTS40-3-2 meal is as safe as its non-transgenic parent soybean A5403 in a long-term SD rat feeding study. The study provides experimental evidence for the safe usage of transgenic soybean GTS40-3-2.
外文关键词：Chronic feeding; Glyphosate-resistant transgenic soybean GTS40-3-2; Meal; Sprague-Dawley rat; Toxicology evaluation
作者：Yuan, Jianqin; Tang, Zhongwei; Zhao, Jianghe; 等.
作者单位：Shanxi Agr Univ
期刊名称：EMIRATES JOURNAL OF FOOD AND AGRICULTURE
期刊影响因子：0.494
出版年份：2017
出版刊次：11
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