中文摘要：光电化学（PEC）生物传感器通常以分析物与探针之间的生物识别活动引起的单光电流的变化为基础。然而，光电流可能受到目标分析物以外的其它因素的影响，带来错误的结果。为了提高PEC分析的精度和可靠性，本研究提出了一种双通道、自反馈PEC生物传感器的设计方案。与传统PEC生物传感器相比，该设计可以提供更好的精度和可靠性，这在PEC检测的发展中具有广阔的应用前景。
外文摘要：Photoelectrochemical (PEC) biosensors are usually based on the single photocurrent change caused by biorecognition events between analytes and probes. However, the photocurrent may be influenced by other factors besides target analytes and bring a false result. To improve the accuracy and reliability of PEC detection, here we proposed the design of a dual channel self-reference PEC biosensors. CdTe and CdTe-graphene oxide (GO) were chosen as the two PEC active material and modified onto two adjacent areas on the ITO electrode. Then they were functionalized with Aflatoxin B1（AFB1）aptamer through covalent binding or physical adsorption respectively. The cathodic current from CdTe-GO and anodic current from CdTe can be well distinguished by adjusting the bias voltage. With the simultaneous application of "signal on" and "signal off" model, dual concentration information may be obtained in one detection and serve as a reference for each other. By comparing these two results, this sensor can clearly distinguish whether the signal change was caused by AFB1 or other interference factors. Compared to traditional PEC biosensors, this design can provide a better accuracy and reliability, which is promising in the future development of PEC detection.
作者：Hao, N；Zhang, Y；Zhong, H；Zhou, Z；Hua, R；Qian, J； Liu, Q；Li, HN；Wang, K
作者单位：Jiangsu Univ
期刊名称：ANALYTICAL CHEMISTRY
期刊影响因子：5.886
出版年份：2017
出版刊次：19
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