中文摘要：黄曲霉毒素B1（AFB1）在自然界尤其是各种食品中广泛存在。它被证实是最有毒的黄曲霉毒素。黄曲霉毒素的毒性目前已经得到了很好的研究，它可导致严重的健康问题，包括致癌、诱变、生长迟缓、免疫抑制等。DNA甲基化、组蛋白修饰和非编码RNA调控导致的表观遗传改变在AFB1诱导疾病和癌症中发生发挥重要作用。为了更好地理解AFB1诱导表观遗传改变的证据和AFB1毒性的潜在机制，本文对AFB1诱导的表观遗传改变进行了综述研究。
外文摘要：Aflatoxin B1 (AFB1) is widely distributed in nature, especially in a variety of food commodities. It is confirmed to be the most toxic of all the aflatoxins. The toxicity of AFB1 has been well investigated, and it may result in severe health problems including carcinogenesis, mutagenesis, growth retardation, and immune suppression. Epigenetic modifications including DNA methylation, histone modifications and regulation of non-coding RNA play an important role in AFB1-induced disease and carcinogenesis. To better understand the evidence for AFB1-induced epigenetic alterations and the potential mechanisms of the toxicity of AFB1, we conducted a review of published studies of AFB1-induced epigenetic alterations. 
 
外文关键词：Aflatoxin B1; Epigenetics; DNA methylation; Histone modifications; Non-coding RNA
作者：Dai, Yaqi; Huang, Kunlun; Zhang, Boyang; 等
作者单位：China Agr Univ
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.778
出版年份：2017
出版刊次：11
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