中文摘要：黄曲霉毒素M1（AFM1）是人和动物消化黄曲霉毒素B1（AFB1）后形成的一种羟基化代谢物；可以在尿液、乳汁及血液中检测到。众所周知AFB1对人和其它动物有毒。国际癌症研究署(IARC)将AFB1归入1类致癌物而将AFM1归入2B类致癌物。本研究旨在评估越南猪的黄曲霉毒素暴露并评价越南五省的人群对黄曲霉毒素的公众意识。研究表明越南的猪不同程度地受到黄曲霉毒素暴露，从而猪肉及其制品可能存在AFM1污染风险。还需要进一步调查可能的健康危害，并协助制定动物饲料的规章制度，降低人和动物的健康危害。
外文摘要：BACKGROUND: Aflatoxin M1 (AFM1) is a hydroxylated metabolite formed after aflatoxin B1 (AFB1) is consumed by humans and animals; it can be detected in urine, milk and blood. It is well recognized that AFB1 is toxic to humans and other animals. The International Agency for Research on Cancer (IARC) classifies aflatoxins as group 1 carcinogens and AFM1 as group 2B carcinogen. The main objective of this study was to evaluate the exposure of pigs to aflatoxins as well as to assess the public awareness of aflatoxins among people in five provinces in Vietnam. RESULTS: A total of 1920 urine samples were collected from slaughterhouses located in five provinces. Overall, the positive rate of AFM1 was 53.90% (95% confidence interval 51.64-56.15) using a cut-off of 0.15 μg/kg (range: limit of detection to 13.66 μg/kg, median: 0.2 μg/kg and mean: 0.63 μg/kg). A total of 252 people from the general population were interviewed from 5 provinces, and overall 67.86% reported being aware of aflatoxins. We also found that men and more highly educated had significantly increased awareness of aflatoxins compared to the females and primary/secondary school group. The respective odds ratios (ORs) were as follows: "male" group (OR: 2.64), "high school educated" group (OR: 3.40) and "college/university or more educated" group (OR: 10.20). CONCLUSIONS: We can conclude that pigs in Vietnam are exposed to aflatoxins to varying degrees, and there may be a risk that pork products could contain AFM1. Further investigation is needed into the possible health impacts as well as to aid in establishing regulations for animal feed to reduce the health impacts in humans and animals.
外文关键词：Vietnam；ELISA；Pig；Urine；Aflatoxins；Survey；Perception/knowledge
作者：Lee, HS；Lindahl, J；Hung, NV；Khong, NV；Nghia, VB；Xuan, HN；Grace, D
作者单位：Int Livestock Res Inst
期刊名称：BMC VETERINARY RESEARCH
期刊影响因子：1.643
出版年份：2017
出版刊次：11
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