中文摘要：复杂基质中微量有毒化合物的检测倍受关注，特别是食品中的霉菌毒素。本研究用简单粗糙的金膜作基底，研发了一种检测赭曲霉毒素A的高度灵敏的特异性SERS传感器。并用脱氧雪腐镰刀菌烯醇和牛血清白蛋白通过负检测试验验证了该传感器检测。
外文摘要：The trace detection of toxic compounds in complex matrices is a major concern, in particular when it comes to mycotoxins in food. We developed a highly sensitive and specific SERS sensor for the detection of ochratoxin A using a simple rough gold film as a substrate. When adding the analyte, we observed spectral variations related to the interaction of the analyte with the specific aptamer used as a bioreceptor. Using a partial least squares regression method, our sensor is able to detect concentrations down to the picomolar range, which is much lower than the minimum legal concentration allowed in food products. Moreover, we demonstrate the accurate detection of the analyte in a wide concentration range from the picomolar up to the micromolar level. The detection was validated with negative detection tests using deoxynivalenol and bovine serum albumin.
作者：Gillibert, R；Triba, MN；de la Chapelle, ML
作者单位：Univ Paris 13
期刊名称：ANALYST
期刊影响因子：4.033
出版年份：2018
出版刊次：1
点击下载：高灵敏度、高选择性检测赭曲霉毒素A的表面增强拉曼散射传感器