中文摘要：脱氧雪腐镰刀菌烯醇(DON)就其在小麦中的数量及发生而言，是最重要的单端孢霉烯族毒素。该化合物与因人类免疫球蛋白A升高引起的肾小球肾炎有关。本研究评估了面粉中DON的发生率及巴西青少年、成年人及老人因摄入面食而造成的该毒素暴露。研究发现，77.9%的样品中DON呈阳性，浓度范围从73.50到2794.63µg/kg。与男性对面包和面食的消费量相比，所有年龄组的女性暴露于DON的水平较高。青少年是面食的主要消费群体，女孩和男孩的最大可能每日摄入量分别为1.28和1.20 µg/kg体重/天。表明巴西该人群DON暴露风险因消费面食而增长。
外文摘要：Deoxynivalenol (DON) is the most important of the trichothecenes in terms of amounts and occurrence in wheat. This compound was shown to be associated with a glomerulonephropathy involving an increase of immunoglobulin A in humans. This study assessed the occurrence of DON in wheat flour and the exposure of Brazilian teenagers, adults and elderly to this mycotoxin due to intake of wheat flour-based products. DON extraction in wheat flour was carried out by solid phase extraction and the quantification was performed by ultra-high proficiency liquid chromatography with diode-array detection. A total of 77.9% of all samples were positive for DON, with concentrations ranging from 73.50 to 2794.63 µg kg−1. The intake was calculated for the average and 90th percentile of the contamination levels of DON in foods based-wheat for teenagers, adults and elderly in Brazil, and compared with the provisional maximum tolerable daily intakes (PMTDI). Females of all age groups were exposed to DON at higher levels when compared to males in regard of consumption of breads and pastas. Teenagers were the main consumers of foods derived from wheat flour, with maximum probable daily intakes of 1.28 and 1.20 µg kg−1 b.w. day−1 for females and males, respectively. This population is at an increased risk of exposure to DON due to consumption of wheat flour-based foods in Brazil.
外文关键词：Deoxynivalenol；Fusarium graminearum；mycotoxins；occurrence；risk assessment；wheat-based products
作者：Silva, MV；Pante, GC；Romoli, JCZ；de Souza, APM；da Rocha, GHO；Ferreira, FD；Feijo, ALR；Moscardi, SMP；de Paula, KR；Bando, E；Nerilo, SB；Machinski, M
作者单位：Univ Estadual Maringa
期刊名称：FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
期刊影响因子：1.878
出版年份：2018
出版刊次：3
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