中文摘要：本文对大鼠进行为期90天的亚慢性毒性研究，以对转基因玉米DAS-40278-9进行安全性评价。作者对一组大鼠分别喂养含有12.5%、25%或50%转基因玉米DAS-40278-9或非转基因玉米的饲料，且对另一组大鼠饲喂基本啮齿动物饮食。通过笼侧和手持式详细的临床观察、眼科检查、体重/体重增加、饲料消耗、血液学、血清化学、器官重量、大体和组织病理学检查来评价动物。研究发现，饲喂转基因玉米DAS-40278-9的大鼠与饲喂非转基因玉米的大鼠相比，并没有引起大鼠任何与治疗相关的影响。
外文摘要：Genetically modified (GM) maize, DAS-40278-9, expresses the aryloxyalkanoate dioxygenase-1 (AAD-1) protein, which confers tolerance to 2,4-dichlorophenoxyacetic acid (2,4-D) and aryloxyphenoxypropionate (AOPP) herbicides. The aad-1 gene, which expresses the AAD-1 protein, was derived from Gram-negative soil bacterium, Sphingobium herbicidovorans. A 90-day sub-chronic toxicity study was conducted on rats as a component of the safety evaluation of DAS-40278-9 maize. Rats were given formulated diets containing maize grain from DAS-40278-9 or a non-GM near isogenic control comparator at an incorporation rate of 12.5%, 25%, or 50% (w/w), respectively for 90 days. In addition, another group of rats was fed a basic rodent diet. Animals were evaluated by cage-side and hand-held detailed clinical observations, ophthalmic examinations, body weights/body weight gains, feed consumption, hematology, serum chemistry, selected organ weights, and gross and histopathological examinations. Under the condition of this study, DAS-40278-9 maize did not cause any treatment-related effects in rats compared with rats fed diets containing non-GM maize.
外文关键词：Maize, Herbicide tolerance, Genetically modified, Safety assessment, 90-Day feeding study
作者：Zou, Shiying; Lang, Tianqi; Liu, Xu; Huang, Kunlun; He, Xiaoyun
作者单位：China Agr Univ
期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY
期刊影响因子：2.815
出版年份：2018
出版刊次：7
点击下载：转基因玉米DAS-40278-9在亚慢性啮齿动物饲养研究中的安全性评价