中文摘要：脱氧雪腐镰刀菌烯醇（DON），主要由禾谷镰刀菌产生并在污染谷物食品中发现的霉菌毒素，一直在成人体液中检测到。而儿童和青少年的可用数据稀少。本研究评估了英国3-9岁(n = 40)的儿童和10-17岁(n = 39)的青少年尿液中DON的浓度。研究表明，虽然平均尿DON浓度为中等，但仍需关注尿DON的高检出频率、最大生物标志物浓度并评估膳食DON暴露。
外文摘要：Deoxynivalenol (DON), the mycotoxin produced mainly by Fusarium graminearum and found in contaminated cereal-based foodstuff, has been consistently detected in body fluids in adults. Available data in children and adolescents are scarce. This study assessed urinary DON concentrations in children aged 3-9 years (n = 40) and adolescents aged 10-17 years (n = 39) in the UK. Morning urine samples were collected over two consecutive days and analysed for free DON (un-metabolised form), DON-glucuronides (DON-GlcA), deepoxy deoxynivalenol (DOM-1), and total DON (sum of free DON, DON-GlcA, and DOM-1). Total DON was detected in the urine of >95% of children and adolescents on both days. Mean total DON concentrations (ng/mg creatinine) were 41.6 and 21.0 for children and adolescents, respectively. The greatest total DON levels were obtained in female children on both days (214 and 219 ng/mg creatinine on days 1 and 2, respectively). Free DON and DON-GlcA were detected in most urine specimens, whereas DOM-1 was not present in any sample. Estimation of dietary DON exposure suggested that 33-63% of children and 5-46% of adolescents exceeded current guidance regarding the maximum provisional tolerable daily intake (PMTDI) for DON. Although moderate mean urinary DON concentrations were shown, the high detection frequency of urinary DON, the maximum biomarker concentrations, and estimated dietary DON exposure are concerning.
外文关键词：mycotoxins；deoxynivalenol；Fusarium graminearum；children；adolescents；biomonitoring
作者：Papageorgiou, M；Wells, L；Williams, C；White, K；De Santis, B；Liu, YR；Debegnach, F；Miano, B；Moretti, G；Greetham, S；Brera, C；Atkin, SL；Hardie, LJ；Sathyapalan, T
作者单位：Univ Hull
期刊名称：TOXINS
期刊影响因子：3.571
出版年份：2018
出版刊次：2
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