中文摘要：黄曲霉毒素B1（AFB1）是一种广泛存在于多种食品中的次生真菌代谢产物，因其遗传毒性及致癌性而被认为是全球性公共卫生问题。印度尼西亚的热带气候及不当的食品安全措施 是AFB1污染食品的有利条件。尽管存在这些挑战，但在印度尼西亚开展AFB1风险评估的数量有限。因此，本文旨在收集所有AFB1在印度尼西亚玉米和花生中发生的数据，并利用发生数据，通过分别由EFSA和FAO/WHO建立的暴露限值(MOE)及定量肝癌风险法，评价AFB1暴露的风险。研究结果揭示了AFB1在印度尼西亚风险管理的紧迫性。
外文摘要：Aflatoxin B1 (AfB1) is a secondary fungal metabolite product widely found in many foodstuffs and considered a public health concern worldwide due to its genotoxicity and carcinogenicity. Tropical climate and inappropriate food safety practices in Indonesia are the favorable conditions for AfB1 contamination of foodstuffs. Despite these challenges, there has been a limited number of risk assessment of AfB1 conducted in Indonesia. Therefore, this paper aimed to gather all available occurrence data of AfB1 in maize and peanut originating from Indonesia and used the occurrence data to evaluate the risk of exposure to AfB1 using the Margin of Exposure (MOE) and the quantitative liver cancer risk approaches established by EFSA and FAO/WHO respectively. Risk assessment using both the MOE and quantitative liver cancer risk approaches revealed that AfB1 exposure from maize and peanut consumption in Indonesia is of concern. The MOE values derived from consumption of maize and peanut originating from Indonesia were generally below 10,000, and for several occurrence data were even below 1000. The estimated number of liver cancer cases associated with AfB1 exposure generally was above the 0.1 cancer cases/100,000 individuals/75 years. Altogether the evaluation reveals the urgency for risk management of AfB1 in Indonesia.
外文关键词：Aflatoxin B1；Risk assessment；MOE；Liver cancer；Maize, Peanut
作者：Nugraha, A；Khotimah, K；Rietjens, IMCM
作者单位：Wageningen Univ
期刊名称：FOOD AND CHEMICAL TOXICOLOGY
期刊影响因子：3.584
出版年份：2018
出版刊次：3
点击下载：用暴露限值及肝癌风险评估法评价印度尼西亚玉米及花生消费带来的黄曲霉毒素B1暴露风险