中文摘要：玉米赤霉烯酮（ZEN）是一种镰刀菌毒素，对动物和人体有异源雌激素效应。ZEN与它的衍生物普遍存在于谷物及谷物制品中。ZEN生物转化时，形成其还原代谢产物，α-玉米赤霉烯醇（α-ZEL）及β-玉米赤霉烯醇(β-ZEL)；α-ZEL甚至比其母体化合物ZEN的毒性还强。由于以往的研究证明了ZEN和ZELs与β-环糊精能形成稳定的复合物，于是可以合理假设，环糊精聚合物可以去除水溶液中的霉菌毒素。本研究采用不溶性β-环糊精珠聚合物(BBP)作霉菌毒素粘合剂，探索从水、缓冲液及玉米啤酒中提取ZEN和ZELs。研究表明，不溶性环糊精珠聚合物可能是将来从污染饮料中去除霉菌毒素的合适工具。
外文摘要：Zearalenone (ZEN) is a Fusarium-derived mycotoxin, exerting xenoestrogenic effects in animals and humans. ZEN and its derivatives commonly occur in cereals and cereal-based products. During the biotransformation of ZEN, its reduced metabolites, α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL), are formed; α-ZEL is even more toxic than the parent compound ZEN. Since previous studies demonstrated that ZEN and ZELs form stable complexes with β-cyclodextrins, it is reasonable to hypothesize that cyclodextrin polymers may be suitable for mycotoxin removal from aqueous solutions. In this study, the extraction of ZEN and ZELs from water, buffers, and corn beer was investigated, employing insoluble β-cyclodextrin bead polymer (BBP) as a mycotoxin-binder. Our results demonstrate that even relatively small amounts of BBP can strongly decrease the mycotoxin content of aqueous solutions (including beer). After the first application of BBP for mycotoxin binding, BBP could be completely reactivated through the elimination of ZEN from the cyclodextrin cavities by washing with a 50 v/v% ethanol-water mixture. Therefore, our study suggests that insoluble cyclodextrin polymers may be suitable tools in the future to deplete mycotoxins from contaminated drinks.
外文关键词：zearalenone；zearalenols；beta-cyclodextrin bead polymer；toxin removal；beer
作者：Poor, M；Faisal, Z；Zand, A；Bencsik, T；Lemli, B；Kunsagi-Mate, S；Szente, L
作者单位：Univ Pecs
期刊名称：TOXINS
期刊影响因子：3.571
出版年份：2018
出版刊次：6
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