中文摘要：本研究采用间接竞争酶联免疫吸附试验(IC-ELISA)，探索了从马拉维三个区（卡松古、姆钦吉和恩科塔科塔）采集的230人血液样品中黄曲霉毒素-赖氨酸(AFB1-lys)加合物的水平，以及从他们各自的农庄采集的花生和玉米样品中黄曲霉毒素B1（AFB1）的水平。本研究报道的马拉维居民血液样品中的AFB1- lys加合物研究尚属首次。研究结果强调亟需干预措施，以减少人群的黄曲霉毒素暴露。
外文摘要：Aflatoxin-lysine (AFB1-lys) adduct levels in blood samples collected from 230 individuals living in three districts of Malawi (Kasungu, Mchinji, and Nkhotakota) and aflatoxin B1 (AFB1) levels in groundnut and maize samples collected from their respective homesteads were determined using indirect competitive enzyme-linked immunosorbent assay (IC-ELISA) methods. AFB1-lys adducts were detected in 67% of blood samples, with a mean concentration of 20.5 ± 23.4 pg/mg of albumin. AFB1 was detected in 91% of groundnut samples and in 70% of maize samples, with mean AFB1 levels of 52.4 and 16.3 μg/kg, respectively. All participants of this study reported consuming maize on a daily basis and consuming groundnuts regularly (mean consumption frequency per week: 3.2 ± 1.7). According to regression analysis, a frequency of groundnut consumption of more than four times per week, being female, and being a farmer were significant (p 1-lys adduct levels in the blood. This is the first report on AFB1-lys adducts in blood samples of residents in Malawi. The results reinforce the urgent need for interventions, aiming at a reduction of aflatoxin exposure of the population.
外文关键词：AFB(1) contamination；AFB(1)-lys adduct；Exposure；Women farmers；Groundnuts；Maize
作者：Seetha, A；Monyo, ES；Tsusaka, TW；Msere, HW；Madinda, F；Chilunjika, T；Sichone, E；Mbughi, D；Chilima, B；Matumba, L
作者单位：Int Crops Res Inst Semi Arid Trop
期刊名称：MYCOTOXIN RESEARCH
期刊影响因子：2.0
出版年份：2018
出版刊次：3
点击下载：马拉维农民血清中的黄曲霉毒素-赖氨酸加合物及相应地区食品（花生、玉米）黄曲霉毒素污染