中文摘要：镰刀菌毒素脱氧雪腐镰刀菌烯醇（DON），人类经常通过膳食摄入。虽然推测老年人对DON的毒性作用敏感，但由于与年龄相关的症状、疾病及DON代谢后的变化，因此缺乏该年龄组的DON生物标志物的可用数据。本研究表征了居住在英国赫尔65岁以上的老年人群(n = 20)尿DON浓度及其代谢物。结果表明，在英国的这一地点，虽然平均总DON浓度处于中等水平，但老年人群DON暴露频繁。未来还需要开展更大范围的研究，探索英国不同地区，乃至全球不同国家的老年人DON暴露的情况。
外文摘要：Deoxynivalenol (DON) is a Fusarium toxin, to which humans are frequently exposed via diet. Although the elderly are speculated to be sensitive to the toxic effects of DON as a result of age-related conditions, disease and altered DON metabolism, there is lack of available data on DON biomarkers in this age group. This study characterised urinary DON concentrations and its metabolites in elderly aged ≥65years (n = 20) residing in Hull, UK. Morning urinary specimens were collected over two consecutive days together with food records to assess dietary intake over a 24h-period prior to each urinary collection. Free DON (un-metabolised), total DON (sum of free DON and DON-glucuronides or DON-GlcA) and de-epoxy deoxynivalenol (DOM-1) were analysed using a validated LC-MS/MS methodology. Total DON above the limit of quantification 0.25 ng/mL was detected in the urine from 90% of elderly men and women on both days. Mean total DON concentrations on day 1 were not different from those on day 2 (elderly men, day 1: 22.2 ± 26.3 ng/mg creatinine (creat), day 2: 28.0 ± 34.4 ng/mg creat, p = 0.95; elderly women, day 1: 22.4 ± 14.6 ng/mg creat, day 2: 29.1 ± 22.8 ng/mg creat, p = 0.58). Free DON and DON-GlcA were detected in 60–70% and 90% of total urine samples, respectively. DOM-1 was absent from all samples; the LoQ for DOM-1 was 0.50 ng/mL. Estimated dietary intake of DON suggested that 10% of the elderly exceeded the maximum provisional tolerable daily intake for DON. In this single-site, UK-based cohort, elderly were frequently exposed to DON, although mean total DON concentrations were reported at moderate levels. Future larger studies are required to investigate DON exposure in elderly from different regions of the UK, but also from different counties worldwide.
外文关键词：Mycotoxins；deoxynivalenol；Fusarium graminearum；biomonitoring；elderly
作者：Papageorgiou, M；Wells, L；Williams, C；White, KLM；De Santis, B；Liu, YR；Debegnach, F；Miano, B；Moretti, G；Greetham, S；Brera, C；Atkin, SL；Hardie, LJ；Sathyapalan, T
作者单位：Univ Hull
期刊名称：FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
期刊影响因子：1.878
出版年份：2018
出版刊次：10
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