中文摘要：生长障碍是坦桑尼亚儿童的一个主要公共卫生问题。膳食中的霉菌毒素是否会影响儿童成长的问题仍然存在。我们检查了坦桑尼亚Haydom地区的114名36个月以下儿童在膳食中接触到黄曲霉毒素和伏马菌素的情况以及其对生长的潜在影响。从24个月大的儿童（N = 60）身上收集的血浆样品中分析黄曲霉毒素B-1-赖氨酸（AFB（1）-lys）加合物，从24至36个月大的儿童（N = 94）身上收集尿样分析尿中伏马菌素B-1（UFB1）。对每个儿童进行人体测量学、社会经济学和营养学参数的测量，并计算每个儿童的生长参数z分数。72％的儿童身上可检测到AFB（1）-lys，平均水平为5.1（95％CI：3.5,6.6）pg / mg；80％可检测到UFB1，平均值为1.3（95％CI：0.8,1.8）ng / ml。对于36个月的儿童来说有75％的发育迟缓率[年龄别身高Z评分（HAZ）<-2]。按照发育迟缓、体重不足[年龄别体重Z评分（WAZ）<-2]或消瘦[高度别体重z分数（WHZ）<-2）来衡量，未发现接触黄曲霉毒素与生长障碍之间有关联。然而，在该组儿童中，接触伏马菌素与体重不足（包括不可检测的样品，p=0.0285；排除不可检测的样品，p=0.005）呈负相关。24个月时接触相对较低的黄曲霉毒素不会导致生长障碍，而基于UFB1生物标志物，24-36个月时接触伏马菌素可能导致坦桑尼亚Haydom地区儿童的高生长障碍率；这可能与他们的母乳喂养和断奶实践有关。
外文摘要：Growth impairment is a major public health issue for children in Tanzania. The question remains as to whether dietary mycotoxins play a role in compromising children's growth. We examined children's exposures to dietary aflatoxin and fumonisin and potential impacts on growth in 114 children under 36 months of age in Haydom, Tanzania. Plasma samples collected from the children at 24 months of age (N = 60) were analyzed for aflatoxin B-1-lysine (AFB(1)-lys) adducts, and urine samples collected between 24 and 36 months of age (N = 94) were analyzed for urinary fumonisin B-1 (UFB1). Anthropometric, socioeconomic, and nutritional parameters were measured and growth parameter z-scores were calculated for each child. Seventy-two percent of the children had detectable levels of AFB(1)-lys, with a mean level of 5.1 (95% CI: 3.5, 6.6) pg/mg albumin; and 80% had detectable levels of UFB1, with a mean of 1.3 (95% CI: 0.8, 1.8) ng/ml. This cohort had a 75% stunting rate [height-for-age z-scores (HAZ) < -2] for children at 36 months. No associations were found between aflatoxin exposures and growth impairment as measured by stunting, underweight [weight-for-age z-scores (WAZ) < -2], or wasting [weight-for-height z-scores (WHZ) < -2]. However, fumonisin exposure was negatively associated with underweight (with non-detectable samples included, p = 0.0285; non-detectable samples excluded, p = 0.005) in this cohort of children. Relatively low aflatoxin exposure at 24 months was not linked with growth impairment, while fumonisin exposure at 24-36 months based on the UFB1 biomarkers may contribute to the high growth impairment rate among children of Haydom, Tanzania; which may be associated with their breast feeding and weaning practices.
外文关键词：Aflatoxin; Fumonisin; Dietary exposure; Biomarkers; Child growth
作者：Chen, Chen; Mitchell, Nicole J.; Gratz, Jean; 等.
作者单位：Michigan State University
期刊名称：ENVIRONMENT INTERNATIONAL
期刊影响因子：7.297
出版年份：2018
出版刊次：-
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